Factors Associated with Severe Leptospirosis, Martinique, 2010–2013

Patrick Hochedez (1, 2) , Rafaelle Theodose (1, 2) , Claude Olive (1, 2) , Pascale Bourhy (3, 4, 5) , Guillaume Hurtrel (1) , Nicolas Vignier (1, 6) , Hossein Mehdaoui (1) , Ruddy Valentino (1) , Roland Martinez (7) , Jean-Marie Delord (8) , Cécile Herrmann (2, 9) , Isabelle Lamaury (2, 9) , Raymond Césaire (1, 2) , Mathieu Picardeau (3, 4, 5) , André Cabié (1, 10)

1 Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique]
2 UAG - Université des Antilles et de la Guyane
3 Centre Collaborateur FAO/OMS pour l'épidémiologie de la leptospirose
4 CNR - Centre National de Référence de la Leptospirose - National Reference Center Leptospirosis
5 Biologie des Spirochètes / Biology of Spirochetes
6 Hôpital Avicenne [AP-HP]
7 Centre hospitalier de Trinité MARTINIQUE
8 Centre hospitalier du Lamentin MARTINIQUE
9 CHU Pointe-à-Pitre/Abymes [Guadeloupe]
10 INSERM - Institut National de la Santé et de la Recherche Médicale

To identify factors associated with disease severity, we examined 102 patients with quantitative PCR-confirmed leptospirosis in Martinique during 2010-2013. Associated factors were hypotension, chest auscultation abnormalities , icterus, oligo/anuria, thrombocytopenia, prothrombin time <68%, high levels of leptospiremia, and infection with L. interrogans serovar Icterohaemorrhagiae/Copenhageni.

Keywords: severe leptospirosis; serogroup Icterohaemorrhagiae; quantitative PCR; qPCR; leptospiremia; bacteria; Martinique; Leptospira interrogans

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Patrick Hochedez, Rafaelle Theodose, Claude Olive, Pascale Bourhy, Guillaume Hurtrel, et al.. Factors Associated with Severe Leptospirosis, Martinique, 2010–2013. Emerging Infectious Diseases, 2015, 21 (12), pp.2221-2224. ⟨10.3201/eid2112.141099⟩. ⟨pasteur-02538324⟩