Factors Associated with Severe Leptospirosis, Martinique, 2010–2013

Patrick Hochedez; Rafaelle Theodose; Claude Olive; Pascale Bourhy; Guillaume Hurtrel; Nicolas Vignier; Hossein Mehdaoui; Ruddy Valentino; Roland Martinez; Jean-Marie Delord; Cécile Herrmann; Isabelle Lamaury; Raymond Césaire; Mathieu Picardeau; André Cabié

doi:10.3201/eid2112.141099

Journal articles

Factors Associated with Severe Leptospirosis, Martinique, 2010–2013

Patrick Hochedez ^{1, 2, *} Rafaelle Theodose ^{1, 2} Claude Olive ^{1, 2} Pascale Bourhy ^{3, 4, 5} Guillaume Hurtrel ¹ Nicolas Vignier ^{1, 6} Hossein Mehdaoui ¹ Ruddy Valentino ¹ Roland Martinez ⁷ Jean-Marie Delord ⁸ Cécile Herrmann ^{2, 9} Isabelle Lamaury ^{2, 9} Raymond Césaire ^{1, 2} Mathieu Picardeau ^{3, 4, 5} André Cabié ^{1, 10}

* Corresponding author

1 Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique]

2 UAG - Université des Antilles et de la Guyane

3 Centre Collaborateur FAO/OMS pour l'épidémiologie de la leptospirose

4 CNR - Centre National de Référence de la Leptospirose - National Reference Center Leptospirosis

5 Biologie des Spirochètes / Biology of Spirochetes

6 Hôpital Avicenne [AP-HP]

7 Centre hospitalier de Trinité MARTINIQUE

8 Centre hospitalier du Lamentin MARTINIQUE

9 CHU Pointe-à-Pitre/Abymes [Guadeloupe]

10 INSERM - Institut National de la Santé et de la Recherche Médicale

Abstract : To identify factors associated with disease severity, we examined 102 patients with quantitative PCR-confirmed leptospirosis in Martinique during 2010-2013. Associated factors were hypotension, chest auscultation abnormalities , icterus, oligo/anuria, thrombocytopenia, prothrombin time <68%, high levels of leptospiremia, and infection with L. interrogans serovar Icterohaemorrhagiae/Copenhageni.

Keywords : severe leptospirosis serogroup Icterohaemorrhagiae quantitative PCR qPCR leptospiremia bacteria Martinique Leptospira interrogans

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Life Sciences [q-bio] / Microbiology and Parasitology

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Factors Associated with Severe Leptospirosis, Martinique, 2010–2013

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Factors Associated with Severe Leptospirosis, Martinique, 2010–2013

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