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, Fig 3. L. interrogans positive sera display IgM and IgG reactivity to leptospiral exoproteins
, Guinea pig sera obtained prior to and post L. interrogans infection were used in protein 771 immunoblot experiments to test immunoglobulin reactivity with whole L. interrogans lysates or 772 culture supernatants. Panel A. Protein immunoblot comparing IgG reactivity with whole cell 773 proteins and exoproteins when using L. interrogans positive sera, Panel B. Protein immunoblot, p.774
, Protein immunoblot demonstrating a lack of IgG reactivity to whole cell 776 and extracellular proteins when using pre-infection sera. Panel D. Protein immunoblot 777 demonstrating a lack of IgM reactivity to whole cell and extracellular proteins when using pre-778 infection sera, comparing IgM reactivity to whole cell proteins and exoproteins when using L. interrogans 775 positive sera. Panel C