Functional analysis of the YopE GTPase-activating protein (GAP) activity of Yersinia pseudotuberculosis, Cell Microbiol, vol.8, pp.1020-1033, 2006. ,
Bacterial protein toxins that modify host regulatory GTPases, Nat. Rev. Microbiol, vol.9, pp.487-498, 2011. ,
Actin as target for modification by bacterial protein toxins, FEBS J, vol.278, pp.4526-4543, 2011. ,
Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src, Mol. Cell Biol, vol.30, pp.4324-4338, 2010. ,
Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation, Sci. Rep, vol.7, p.44779, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02448600
The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells, Infect. Immun, vol.78, pp.4500-4510, 2010. ,
A Burkholderia type VI effector deamidates Rho GTPases to activate the pyrin inflammasome and trigger inflammation, Cell Host Microbe, vol.19, pp.1-11, 2016. ,
Phosphoribosylation of ubiquitin promotes serine ubiquitination and impairs conventional ubiquitination, Cell, vol.167, pp.1636-1649, 2016. ,
Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?, Trends Cell Biol, vol.13, pp.238-246, 2003. ,
Evolution of the Rho family of ras-like GTPases in eukaryotes, Mol Biol Evol, vol.24, pp.203-216, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00203003
Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth, FEBS Lett, vol.579, pp.1015-1019, 2005. ,
High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer, PLoS One, vol.8, p.56964, 2013. ,
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases, Science, vol.282, pp.1717-1721, 1998. ,
Serine phosphorylation negatively regulates RhoA in vivo, J. Biol. Chem, vol.278, pp.19023-19031, 2003. ,
Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine, Nature, vol.387, pp.729-733, 1997. ,
Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes, Biochem. J, vol.361, pp.243-254, 2002. ,
Eukaryotic cell determination of ExoS ADP-ribosyltransferase substrate specificity, Biochem. Biophys. Res. Commun, vol.291, pp.91-100, 2002. ,
Common themes in the design and function of bacterial effectors, Cell Host Microbe, vol.5, pp.571-579, 2009. ,
Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression, Oncogene, vol.34, pp.5395-5405, 2015. ,
Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II type 2 receptor activation, Circ. Res, vol.102, pp.1265-1274, 2008. ,
Regulating Rho GTPases and their regulators, Nat. Rev. Mol. Cell Biol, vol.17, pp.496-510, 2016. ,
Legionella pneumophila proteins that regulate Rab1 membrane cycling, Nature, vol.450, pp.365-369, 2007. ,
A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins, Nat. Struct. Mol. Biol, vol.20, pp.1273-1280, 2013. ,
Glucosylation of Rho proteins by Clostridium difficile toxin B, Nature, vol.375, pp.500-503, 1995. ,
Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1, J. Biol. Chem, vol.275, pp.423-428, 2000. ,
Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering, Science, vol.327, pp.1139-1142, 2010. ,
Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes, EMBO J, vol.15, pp.510-519, 1996. ,
Hijacking of Rho GTPases during bacterial infection, Exp. Cell Res, vol.319, pp.2329-2336, 2013. ,
General aspects and recent advances on bacterial protein toxins, Cold Spring Harb. Perspect. Med, vol.3, pp.1-13, 2013. ,
Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells, Infect. Immun, vol.67, pp.496-503, 1999. ,
Rho GTPase regulation by miRNAs and covalent modifications, Trends Cell Biol, vol.22, pp.365-373, 2012. ,
Rab GTPases and the autophagy pathway: bacterial targets for a suitable biogenesis and trafficking of their own vacuoles, Cells, vol.5, p.11, 2016. ,
Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection, J. Biol. Chem, vol.286, pp.16861-16870, 2011. ,
Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin, EMBO J, vol.19, pp.521-530, 2000. ,
Ubiquitylation of active Rac1 by the E3 ubiquitinligase HACE1, Small GTPases, vol.3, pp.102-106, 2012. ,
Modulation of Rab GTPase function by a protein phosphocholine transferase, Nature, vol.477, pp.103-106, 2011. ,
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b, Science, vol.329, pp.946-949, 2010. ,
A palmitoylation switch mechanism regulates Rac1 function and membrane organization, EMBO J, vol.31, pp.534-551, 2012. ,
Identification of a molecular target for the Yersinia protein kinase A, Mol. Cell, vol.26, pp.465-477, 2007. ,
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell, vol.81, pp.53-62, 1995. ,
Serine phosphorylation differentially affects RhoA binding to effectors: implications to NGF-induced neurite outgrowth, Cell Signal, vol.18, pp.704-714, 2006. ,
Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors, 2016. ,
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity, Science, vol.307, pp.1603-1609, 2005. ,
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS, Nat. Immunol, vol.17, pp.914-921, 2016. ,
Microinjection of recombinant p21rho induces rapid changes in cell morphology, J. Cell Biol, vol.111, pp.1001-1007, 1990. ,
Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host. Small GTPases 5, e28209, Cell, vol.126, pp.869-880, 2006. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01797609
Ubiquitination independent of E1 and E2 enzymes by bacterial effectors, Nature, vol.533, pp.120-124, 2016. ,
Lipopolysaccharideinduced lung injury involves the nitration-mediated activation of RhoA, J. Biol. Chem, vol.289, pp.4710-4722, 2014. ,
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, vol.70, pp.389-399, 1992. ,
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell, vol.70, pp.401-410, 1992. ,
Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells, Circ. Res, vol.96, pp.1152-1160, 2005. ,
URL : https://hal.archives-ouvertes.fr/inserm-00000098
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response, Proc. Natl. Acad. Sci. USA, vol.111, pp.3032-3037, 2014. ,
Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects, Exp. Cell Res, vol.299, pp.356-369, 2004. ,
Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1, Nature, vol.387, pp.725-729, 1997. ,
Uncovering an important role for YopJ in the inhibition of caspase-1 in activated macrophages and promoting Yersinia pseudotuberculosis virulence, Infect. Immun, vol.84, pp.1062-1072, 2016. ,
Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase, J. Biol. Chem, vol.264, pp.8602-8605, 1989. ,
Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins, J. Biol. Chem, vol.271, pp.25173-25177, 1996. ,
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases, Proc. Natl. Acad. Sci. USA, vol.100, pp.904-909, 2003. ,
PKC ? phosphorylates and mediates the cell membrane localization of RhoA, ISRN Oncol, p.329063, 2013. ,
Ubiquitin modifications, Cell Res, vol.26, pp.399-422, 2016. ,
Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination, Proc. Natl. Acad. Sci. USA, vol.108, pp.21212-21217, 2011. ,
Legionella pneumophila SidD is a deAMPylase that modifies Rab1, Nature, vol.475, pp.506-509, 2011. ,
Phosphorylation of Rac1 T108 by extracellular signal-regulated kinase in response to epidermal growth factor: a novel mechanism to regulate Rac1 function, Mol. Cell Biol, vol.33, pp.4538-4551, 2013. ,
The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1, Dev. Cell, vol.21, pp.959-965, 2011. ,
The tumor suppressor Hace1 is a critical regulator of TNFR1-mediated cell fate, Cell Rep, vol.15, pp.1481-1492, 2016. ,
Yersinia outer proteins: Yops, Cell Microbiol, vol.10, pp.557-565, 2008. ,
Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase, J. Biol. Chem, vol.278, pp.49293-49300, 2003. ,
Direct modifications of Rho proteins: deconstructing GTPase regulation, Biol. Cell, vol.102, pp.377-389, 2010. ,
Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release, Cell, vol.115, pp.851-862, 2003. ,
Rab proteins and the compartmentalization of the endosomal system, Cold Spring Harb. Perspect. Biol, vol.6, 2014. ,
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation, Science, vol.302, pp.1775-1779, 2003. ,
A new mechanism of RhoA ubiquitination and degradation: roles of SCF(FBXL19) E3 ligase and Erk2, Biochim. Biophys. Acta, vol.1833, pp.2757-2764, 2013. ,
Uropathogenic Escherichia coli-associated exotoxins, Microbiol. Spectr, vol.4, 2016. ,
Structure-function relationships of the G domain, a canonical switch motif, Annu. Rev. Biochem, vol.80, pp.943-971, 2011. ,
The fic domain: regulation of cell signaling by adenylylation, Mol. Cell, vol.34, pp.93-103, 2009. ,
Innate immune sensing of bacterial modifications of Rho GTPases by the pyrin inflammasome, Nature, vol.513, pp.237-241, 2014. ,
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling, Science, vol.323, pp.269-272, 2009. ,
Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on selfassembled human protein microarrays, Mol. Cell Proteom, vol.13, pp.3164-3176, 2014. ,
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers, Nat. Med, vol.13, pp.1060-1069, 2007. ,
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress, Nat. Commun, vol.5, p.3430, 2014. ,
SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation, FASEB J, vol.27, pp.2611-2619, 2013. ,
Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence, Curr. Opin. Microbiol, vol.29, pp.37-42, 2016. ,