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Journal Articles Nature Communications Year : 2019

Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei

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Pieter-Jan Ceyssens
  • Function : Author
  • PersonId : 1010845

Abstract

Shigella sonnei increasingly dominates the international epidemiological landscape of shi-gellosis. Treatment options for S. sonnei are dwindling due to resistance to several key antimicrobials, including the fluoroquinolones. Here we analyse nearly 400 S. sonnei whole genome sequences from both endemic and non-endemic regions to delineate the evolutionary history of the recently emergent fluoroquinolone-resistant S. sonnei. We reaffirm that extant resistant organisms belong to a single clonal expansion event. Our results indicate that sequential accumulation of defining mutations (gyrA-S83L, parC-S80I, and gyrA-D87G) led to the emergence of the fluoroquinolone-resistant S. sonnei population around 2007 in South Asia. This clone was then transmitted globally, resulting in establishments in Southeast Asia and Europe. Mutation analysis suggests that the clone became dominant through enhanced adaptation to oxidative stress. Experimental evolution reveals that under fluoroquinolone exposure in vitro, resistant S. sonnei develops further intolerance to the antimicrobial while the susceptible counterpart fails to attain complete resistance.
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Dates and versions

pasteur-02481816 , version 1 (17-02-2020)

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Attribution - CC BY 4.0

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Hao Chung The, Christine Boinett, Duy Pham Thanh, Claire R Jenkins, François-Xavier Weill, et al.. Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei. Nature Communications, 2019, 10 (1), pp.4828. ⟨10.1038/s41467-019-12823-0⟩. ⟨pasteur-02481816⟩

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