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A Transgenic Model for Listeriosis: Role of Internalin in Crossing the Intestinal Barrier

Abstract : Listeria monocytogenes is responsible for severe food-borne infections, but the mechanisms by which bacteria cross the intestinal barrier are unknown. Listeria monocytogenes expresses a surface protein, internalin, that interacts with a host receptor, E-cadherin, to promote entry into human epithelial cells. Murine E-cadherin, in contrast to guinea pig E-cadherin, does not interact with internalin, excluding the mouse as a model for addressing internalin function in vivo. In guinea pigs and transgenic mice expressing human E-cadherin, internalin was found to mediate invasion of enterocytes and crossing of the intestinal barrier. These results illustrate how relevant animal models for human infections can be generated.
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Submitted on : Monday, January 27, 2020 - 3:49:36 PM
Last modification on : Monday, May 9, 2022 - 11:58:08 AM

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M. Lecuit, S Vandormael-Pournin, J Lefort, M. Huerre, P. Gounon, et al.. A Transgenic Model for Listeriosis: Role of Internalin in Crossing the Intestinal Barrier. Science, 2001, 292 (5522), pp.1722-1725. ⟨10.1126/science.1059852⟩. ⟨pasteur-02456808⟩

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