Antibody-coated microbiota in nasopharynx of healthy individuals and hypogammaglobulinemia patients.

Pedro Goncalves (1) , Bruno Charbit (2) , Christelle Lenoir (3) , Darragh Duffy (4, 2) , Alain Fischer (3, 5, 6) , James Di Santo (1)

1 Immunité Innée - Innate Immunity
2 CRT - Centre de Recherche Translationnelle - Center for Translational Science
3 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
4 Immunobiologie des Cellules dendritiques
5 CHU Necker - Enfants Malades [AP-HP]
6 Collège de France - Chaire Médecine expérimentale (A. Fischer)

We show that nasopharyngeal microbiota are coated by different immunoglobulin isotypes in healthy individuals and with IgG in X-linked agammaglobulinemia (XLA) patients treated with immunoglobulin replacement therapy.

Keywords: antibody-coated microbiota; X-linked (Bruton’s) agammaglobulinemia patients; Immunoglobulin (IgG) replacement therapy; IgD; IgG; healthy; human nasopharynx microbiota; microbiota dysbiosis; sIgA; sIgM

Domains: Immunology

Pedro Goncalves, Bruno Charbit, Christelle Lenoir, Darragh Duffy, Alain Fischer, et al.. Antibody-coated microbiota in nasopharynx of healthy individuals and hypogammaglobulinemia patients.. 2020. ⟨pasteur-02456258⟩