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Prevention of Infections During Primary Immunodeficiency

Claire Aguilar 1, 2 Marion Malphettes 3, 2 Jean Donadieu 4, 2 Olivia Chandesris 2, 5 Hélène Coignard-Biehler 2, 1, 5 Emilie Catherinot 2, 6 Isabelle Pellier 2, 7 Jean-Louis Stéphan 2, 8 Vincent Le Moing 9, 2 Vincent Barlogis 10, 2 Felipe Suarez 2, 5, 11 Stéphane Gérart 5 Fanny Lanternier 2, 5, 1 Arnaud Jaccard 12, 2 Paul-Henri Consigny 1 Florence Moulin 11 Odile Launay 13 Marc Lecuit 11, 14, 15, 16, 2 Olivier Hermine 15, 16, 2 Eric Oksenhendler 2, 17 Capucine Picard 2, 11, 16 Stéphane Blanche 18, 2, 16 Alain Fischer 2, 16, 11, 19 Nizar Mahlaoui 2, 16, 11 Olivier Lortholary 1, 2, 16, *
Abstract : Because infectious diseases are a major source of morbidity and mortality in the majority of patients with primary immunodeficiencies (PIDs), the application of a prophylactic regimen is often necessary. However, because of the variety of PIDs and pathogens involved, and because evidence is scarce, practices are heterogeneous. To homog-enize practices among centers, the French National Reference Center for PIDs aimed at elaborating recommendations for anti-infectious prophylaxis for the most common PIDs. We performed a literature review of infectious complications and prophylactic regimens associated with the most frequent PIDs. Then, a working group including different specialists systematically debated about chemoprophylaxis, immunotherapy, immunization, and recommendations for patients. Grading of prophylaxis was done using strength of recommendations (decreasing from A to D) and evidence level (decreasing from I to III). These might help infectious diseases specialists in the management of PIDs and improving the outcome of patients with PIDs.
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Claire Aguilar, Marion Malphettes, Jean Donadieu, Olivia Chandesris, Hélène Coignard-Biehler, et al.. Prevention of Infections During Primary Immunodeficiency. Clinical Infectious Diseases, Oxford University Press (OUP), 2014, 59 (10), pp.1462-1470. ⟨10.1093/cid/ciu646⟩. ⟨pasteur-02454019⟩

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