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Journal articles
Antibodies and Vaccines Against Botulinum Toxins: Available Measures and Novel Approaches
Abstract : Botulinum neurotoxin (BoNT) is produced by the anaerobic, Gram-positive bacterium Clostridium botulinum. As one of the most poisonous toxins known and a potential bioterrosism agent, BoNT is characterized by a complex mode of action comprising: internalization, translocation and proteolytic cleavage of a substrate, which inhibits synaptic exocytotic transmitter release at neuro-muscular nerve endings leading to peripheral neuroparalysis of the skeletal and autonomic nervous systems. There are seven major serologically distinct toxinotypes (A-G) of BoNT which act on different substrates. Human botulism is generally caused by BoNT/A, B and E. Due to its extreme lethality and potential use as biological weapon, botulism remains a global public health concern. Vaccination against BoNT, although an effective strategy, remains undesirable due to the growing expectation around therapeutic use of BoNTs in various pathological conditions. This review focuses on the current approaches for botulism control by immunotherapy, highlighting the future challenges while the molecular underpinnings among subtypes variants and BoNT sequences found in non-clostridial species remain to be elucidated.
Cited literature [132 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02453849
Contributor : Nadine Delarue Connect in order to contact the contributor
Submitted on : Friday, January 24, 2020 - 9:52:00 AM
Last modification on : Wednesday, November 3, 2021 - 6:42:22 AM
Long-term archiving on: : Saturday, April 25, 2020 - 1:09:48 PM
Contributor : Nadine Delarue Connect in order to contact the contributor
Submitted on : Friday, January 24, 2020 - 9:52:00 AM
Last modification on : Wednesday, November 3, 2021 - 6:42:22 AM
Long-term archiving on: : Saturday, April 25, 2020 - 1:09:48 PM
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