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Variability of Botulinum Toxins: Challenges and Opportunities for the Future

Christine Rasetti-Escargueil 1, 2 Emmanuel Lemichez 1, 2 Michel R. Popoff 1, 2, * 
* Corresponding author
1 Toxines bactériennes - Bacterial Toxins
Institut Pasteur [Paris], UPD7 - Université Paris Diderot - Paris 7, CNRS - Centre National de la Recherche Scientifique : ERL6002
Abstract : Botulinum neurotoxins (BoNTs) are the most potent known toxins, and are therefore classified as extremely harmful biological weapons. However, BoNTs are therapeutic drugs that are widely used and have an increasing number of applications. BoNTs show a high diversity and are divided into multiple types and subtypes. Better understanding of the activity at the molecular and clinical levels of the natural BoNT variants as well as the development of BoNT-based chimeric molecules opens the door to novel medical applications such as silencing the sensory neurons at targeted areas and dermal restoration. This short review is focused on BoNTs' variability and the opportunities or challenges posed for future clinical applications.
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Christine Rasetti-Escargueil, Emmanuel Lemichez, Michel R. Popoff. Variability of Botulinum Toxins: Challenges and Opportunities for the Future. Toxins, MDPI, 2018, 10 (9), pp.374. ⟨10.3390/toxins10090374⟩. ⟨pasteur-02453834⟩



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