Skip to Main content Skip to Navigation
Journal articles

The potential of whole genome NGS for infectious disease diagnosis

Abstract : Non-targeted identification of microbes is now possible directly in biological samples, based on whole-genome-NGS (WG-NGS) techniques that allow deep sequencing of nucleic acids, data mining and sorting out of sequences of pathogens without any a priori hypothesis. WG-NGS was first only used as a research tool due to its cost, complexity and lack of standardization. Recent improvements in sample preparation and bioinformatics pipelines and decrease in cost now allow actionable diagnostics in patients. The potency and limits of WG-NGS and possible future indications are discussed here. WG-NGS will likely soon become a standard procedure in microbiological diagnosis.
Complete list of metadatas

Cited literature [17 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02452595
Contributor : Andrée Diakite <>
Submitted on : Thursday, January 23, 2020 - 3:20:47 PM
Last modification on : Monday, May 25, 2020 - 9:50:04 AM

Identifiers

Collections

Citation

Marc Lecuit, Marc Eloit. The potential of whole genome NGS for infectious disease diagnosis. Expert Review of Molecular Diagnostics, Expert Reviews (formerly Future Drugs), 2015, 15 (12), pp.1517-1519. ⟨10.1586/14737159.2015.1111140⟩. ⟨pasteur-02452595⟩

Share

Metrics

Record views

334