Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies

Bénédicte Neven (1, 2, 3) , Philippe Perot (4, 5) , Julie Bruneau (6) , Marlène Pasquet (7, 8) , Marie Ramirez (5) , Jean-Sébastien Diana (1, 3) , Stéphanie Luzi (9) , Nicole Corre-Catelin (10) , Christophe Chardot (11) , Despina Moshous (1, 2, 3) , Stéphanie Leclerc Mercier (6, 12) , Nizar Mahlaoui (2, 1) , Nathalie Aladjidi (13, 14) , Brigitte Le Bail (15) , Marc Lecuit (16, 17, 18, 19, 2, 3) , Christine Bodemer (12) , Thierry Jo Molina (20, 3) , Stéphane Blanche (1, 2, 3) , Marc Eloit (5)

1 Service d'immuno-hématologie pédiatrique [CHU Necker]
2 CEREDIH - Centre de Référence Déficits Immunitaires Héréditaires
3 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
4 Biomics (plateforme technologique)
5 Découverte de Pathogènes - Pathogen Discovery
6 Département de Pathologie [CHU Necker]
7 Sercice Hématologie, immunologie et oncologie pédiatrique [CHU Toulouse]
8 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
9 Service de radiologie [CHU Necker]
10 ICAReB - Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources
11 Service de Chirurgie Viscérale Pédiatrique [Hôpital Necker-Enfants malades - APHP]
12 Service de dermatologie [CHU Necker]
13 Hématologie et cancérologie pédiatrique [CHU Bordeaux]
14 CIC Bordeaux
15 Laboratoire d'anatomie pathologique
16 UPD5 - Université Paris Descartes - Paris 5
17 CHU Necker - Enfants Malades [AP-HP]
18 Service des Maladies infectieuses et tropicales [CHU Necker]
19 Biologie des Infections - Biology of Infection
20 Service de pathologie [CHU Necker]

Persistence of rubella live vaccine has been associated with chronic skin granuloma in 3 children with primary immunode-ficiency. We describe 6 additional children with these findings, including 1 with visceral extension to the spleen.

Keywords: rubella; granuloma; skin; spleen; vaccine

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Microbiology and Parasitology; Virology; Immunology

Bénédicte Neven, Philippe Perot, Julie Bruneau, Marlène Pasquet, Marie Ramirez, et al.. Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies. Clinical Infectious Diseases, 2016, 64 (1), pp.83-86. ⟨10.1093/cid/ciw675⟩. ⟨pasteur-02452321⟩