C. Burgess, Eliminating maternal and neonatal tetanus and closing the immunity gap, Lancet, vol.389, pp.1380-1381, 2017.

N. F. Fairweather and V. A. Lyness, The complete nucleotide sequence of tetanus toxin, Nucleic. Acids Res, vol.14, pp.7809-7812, 1986.

U. Eisel, Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins, EMBO J, vol.5, pp.2495-2502, 1986.

C. W. Finn, The structural gene for tetanus neurotoxin is on a plasmid, Science, vol.224, pp.881-884, 1984.

G. Schiavo, Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc, EMBO J, vol.11, pp.3577-3583, 1992.

G. Schiavo, O. Rossetto, A. Santucci, B. R. Dasgupta, and C. Montecucco, Botulinum neurotoxins are zinc proteins, J. Biol. Chem, vol.267, pp.23479-23483, 1992.

K. Bercsenyi, Tetanus toxin entry. Nidogens are therapeutic targets for the prevention of tetanus, Science, vol.346, pp.1118-1123, 2014.

S. Surana, The travel diaries of tetanus and botulinum neurotoxins, Toxicon, vol.147, pp.58-67, 2018.

, Tetanus vaccines: WHO position paper, Wkly Epidemiol Rec, vol.92, pp.53-76, 2017.

H. Brüggemann, The genome sequence of Clostridium tetani, the causative agent of tetanus disease, Proc. Ntl. Acad. Sci. (USA), vol.100, pp.1316-1321, 2003.

P. E. Fournier, Genome of a chronic osteitis-causing Clostridium tetani, New Microbes New Infect, vol.2, pp.25-26, 2014.

J. E. Cohen, R. Wang, R. F. Shen, W. W. Wu, and J. E. Keller, Comparative pathogenomics of Clostridium tetani, PLoS One, vol.12, p.182909, 2017.

H. Brüggemann, Genomics of Clostridium tetani. Res Microbiol, vol.166, pp.326-331, 2015.

J. C. Marvaud, U. Eisel, T. Binz, H. Niemann, and M. R. Popoff, tetR is a positive regulator of the Tetanus toxin gene in Clostridium tetani and is homologous to botR, Infect. Immun, vol.66, pp.5698-5702, 1998.

R. P. Fagan, A proposed nomenclature for cell wall proteins of Clostridium difficile, J Med Microbiol, vol.60, pp.1225-1228, 2011.

O. Qazi, Identification and characterization of the surface-layer protein of Clostridium tetani, FEMS Microbiol Lett, vol.274, pp.126-131, 2007.

G. Masuyer, J. Conrad, and P. Stenmark, The structure of the tetanus toxin reveals pH-mediated domain dynamics, EMBO Rep, vol.18, pp.1306-1317, 2017.

N. P. Minton, Molecular genetics of clostridial neurotoxins, Curr. Top. Microbiol. Immunol, vol.195, pp.161-194, 1995.

G. Schiavo, Tetanus and Botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin, Nature, vol.359, pp.832-835, 1992.

M. J. Mansfield and A. C. Doxey, Genomic insights into the evolution and ecology of botulinum neurotoxins, Pathog Dis, vol.76, issue.4, p.4978416, 2018.

A. C. Doxey, M. D. Lynch, K. M. Muller, E. M. Meiering, and B. J. Mcconkey, Insights into the evolutionary origins of clostridial neurotoxins from analysis of the Clostridium botulinum strain A neurotoxin gene cluster, BMC Evol Biol, vol.8, p.316, 2008.

M. R. Popoff and P. Bouvet, Genetic characteristics of toxigenic Clostridia and toxin gene evolution, Toxicon, vol.75, pp.63-89, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-01793259

K. Inui, Toxic and nontoxic components of botulinum neurotoxin complex are evolved from a common ancestral zinc protein, Biochem Biophys Res Commun, vol.419, pp.500-504, 2012.

S. Gu, Botulinum neurotoxin is shielded by NTNHA in an interlocked complex, Science, vol.335, pp.977-981, 2012.

B. Poulain, J. Molgo, and M. R. Popoff, The Comprehensive Sourcebook of Bacterial Protein Toxins, vol.11, pp.287-336, 2015.

S. Gu and R. Jin, Assembly and function of the botulinum neurotoxin progenitor complex, Curr Top Microbiol Immunol, vol.364, pp.21-44, 2013.

M. W. Peck, Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature, Toxins (Basel), vol.9, p.38, 2017.
URL : https://hal.archives-ouvertes.fr/pasteur-01821691

A. C. Doxey, M. J. Mansfield, and C. Montecucco, Discovery of novel bacterial toxins by genomics and computational biology, Toxicon, vol.147, pp.2-12, 2018.

A. Rummel, Two Feet on the Membrane: Uptake of Clostridial Neurotoxins, Curr Top Microbiol Immunol, vol.406, pp.1-37, 2017.

M. J. Mansfield, J. B. Adams, and A. C. Doxey, Botulinum neurotoxin homologs in non-Clostridium species, FEBS Lett, vol.589, pp.342-348, 2015.

M. R. Popoff and . Botulinum, Neurotoxins: Still a Privilege of Clostridia?, Cell Host Microbe, vol.23, pp.145-146, 2018.

S. Zhang, Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium, Cell Host Microbe, vol.23, pp.169-176, 2018.

A. T. Carter, J. W. Austin, K. A. Weedmark, C. Corbett, and M. W. Peck, Three classes of plasmid (47-63 kb) carry the type B neurotoxin gene cluster of group II Clostridium botulinum, Genome Biol Evol, vol.6, pp.2076-2087, 2014.

G. Franciosa, A. Maugliani, C. Scalfaro, and P. Aureli, Evidence that plasmid-borne botulinum neurotoxin type B genes are widespread among Clostridium botulinum serotype B strains, PLoS One, vol.4, p.4829, 2009.

E. M. Nawrocki, M. Bradshaw, and E. A. Johnson, Botulinum neurotoxin-encoding plasmids can be conjugatively transferred to diverse clostridial strains, Sci Rep, vol.8, p.3100, 2018.

P. A. Keyel, M. E. Heid, and R. D. Salter, Macrophage responses to bacterial toxins: a balance between activation and suppression, Immunol Res, vol.50, pp.118-123, 2011.

R. K. Tweten, E. M. Hotze, and K. R. Wade, The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria, Annu Rev Microbiol, vol.69, pp.323-340, 2015.

R. P. Fagan and N. F. Fairweather, Biogenesis and functions of bacterial S-layers, Nat Rev Microbiol, vol.12, pp.211-222, 2014.

S. Pechine, J. F. Bruxelle, C. Janoir, and A. Collignon, Targeting Clostridium difficile Surface Components to Develop Immunotherapeutic Strategies Against Clostridium difficile Infection, Front Microbiol, vol.9, p.1009, 2018.

N. Mori and T. Takahashi, Characteristics and Immunological Roles of Surface Layer Proteins in Clostridium difficile, Ann Lab Med, vol.38, pp.189-195, 2018.

M. R. Popoff, J. P. Guillou, and J. P. Carlier, Taxonomic position of lecithinase-negative strains of Clostridium sordellii, J. Gen. Microbiol, vol.131, pp.1697-1703, 1985.

S. S. Dineen, M. Bradshaw, and E. A. Johnson, Neurotoxin gene clusters in Clostridium botulinum type A strains: sequence comparison and evolutionary implications, Cur. Microbiol, vol.46, pp.342-352, 2003.

D. Desvillechabrol, Sequanix: a dynamic graphical interface for Snakemake workflows, Bioinformatics, vol.34, pp.1934-1936, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01874933

T. J. Treangen, B. D. Ondov, S. Koren, and A. M. Phillippy, The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes, Genome Biol, vol.15, p.524, 2014.

R. K. Aziz, The RAST Server: rapid annotations using subsystems technology, BMC Genomics, vol.9, p.7, 2008.

K. Tamura, G. Stecher, D. Peterson, A. Filipski, S. Kumar et al., Molecular Evolutionary Genetics Analysis version 6.0, Mol Biol Evol, vol.30, pp.2725-2729, 2013.

N. F. Alikhan, N. K. Petty, N. L. Ben-zakour, and S. A. Beatson, BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons, BMC Genomics, vol.12, p.402, 2011.

M. Lechner, Proteinortho: detection of (co-)orthologs in large-scale analysis, BMC Bioinformatics, vol.12, p.124, 2011.

P. Y. Levy, Clostridium tetani osteitis without tetanus, Emerg Infect Dis, vol.20, pp.1571-1573, 2014.