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Journal articles
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Mohammed Sebaihia
1
Brendan Wren
2
Peter Mullany
3
Neil Fairweather
4
Nigel Minton
5
Richard Stabler
2
Nicholas Thomson
1
Adam Roberts
3
Ana Cerdeño-Tárraga
1
Hongmei Wang
3
Matthew Tg Holden
1
Anne Wright
4
Carol Churcher
1
Michael Quail
1
Stephen Baker
1
Nathalie Bason
1
Karen Brooks
1
Tracey Chillingworth
1
Ann Cronin
1
Paul Davis
1
Linda Dowd
1
Audrey Fraser
1
Theresa Feltwell
1
Zahra Hance
1
Simon Holroyd
1
Kay Jagels
1
Sharon Moule
1
Karen Mungall
1
Claire Price
1
Ester Rabbinowitsch
1
Sarah Sharp
1
Mark Simmonds
1
Kim Stevens
1
Louise Unwin
1
Sally Whithead
1
Bruno Dupuy
6
Gordon Dougan
1
Bart Barrell
1
Julian Parkhill
1, *
*
Corresponding author
1
The Wellcome Trust Sanger Institute [Cambridge] (Hinxton, Cambridge CB10 1SA, UK - United Kingdom)
2
LSHTM - Department of Infectious and Tropical Diseases (London WC1 E7HT - United Kingdom)
- LSHTM - London School of Hygiene and Tropical Medicine (Keppel Street London WC1E 7HT - United Kingdom)
3
Eastman Dental Institute [UCL, London] (Gower St, London WC1E 6BT - United Kingdom)
- UCL - University College of London [London] (Gower Street, London WC1E 6BT - United Kingdom)
4
CMBI - MRC Centre for Molecular Microbiology and Infection [Imperial College, London] (Flowers Building, South Kensington Campus, London SW7 2AZ, UK - United Kingdom)
- Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
5
CBS - Centre for Biomolecular Sciences [Nottingham, UK] (University of Nottingham,
University Park,
Nottingham,
NG7 2RD,
UK - United Kingdom)
- UON - University of Nottingham, UK (University of Nottingham University Park Nottingham NG7 2RD - United Kingdom)
6
Génétique Moléculaire Bactérienne (28 rue du Docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
Abstract : We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the genome consists of mobile genetic elements, mainly in the form of conjugative transposons. These mobile elements are putatively responsible for the acquisition by C. difficile of an extensive array of genes involved in antimicrobial resistance, virulence, host interaction and the production of surface structures. The metabolic capabilities encoded in the genome show multiple adaptations for survival and growth within the gut environment. The extreme genome variability was confirmed by whole-genome microarray analysis; it may reflect the organism's niche in the gut and should provide information on the evolution of virulence in this organism.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02444071
Contributor : Nadine Delarue <>
Submitted on : Friday, January 17, 2020 - 3:44:23 PM
Last modification on : Monday, January 20, 2020 - 11:33:22 AM
Contributor : Nadine Delarue <>
Submitted on : Friday, January 17, 2020 - 3:44:23 PM
Last modification on : Monday, January 20, 2020 - 11:33:22 AM
Identifiers
- HAL Id : pasteur-02444071, version 1
- DOI : 10.1038/ng1830
- PUBMED : 16804543
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Citation
Mohammed Sebaihia, Brendan Wren, Peter Mullany, Neil Fairweather, Nigel Minton, et al.. The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nature Genetics, Nature Publishing Group, 2006, 38 (7), pp.779-786. ⟨10.1038/ng1830⟩. ⟨pasteur-02444071⟩
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