Skip to Main content Skip to Navigation
Journal articles

Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?

Abstract : The finding that the Warburg effect observed in proliferating cancer cells is also observed during immune responses renewed the interest in the study of metabolic reprogramming of immune cells, a field of investigation called immunometabolism. However, the specific mechanisms and processes underlying metabolic changes of host cells upon bacterial infection remain poorly understood. Several recent reports have reported that mammalian cells infected with intracellular bacteria have an altered metabolism that resembles the Warburg effect seen in cancer cells. In this Review, we will summarize current knowledge on metabolic reprogramming and discuss putative causes underlying the preferential remodelling of host cells to Warburg-like metabolic programs during infection by intracellular bacteria.
Document type :
Journal articles
Complete list of metadatas

Cited literature [123 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02437195
Contributor : Isabelle Hoffmann <>
Submitted on : Monday, May 18, 2020 - 2:41:22 PM
Last modification on : Wednesday, May 20, 2020 - 6:39:26 PM

File

2018 FEBS_Escoll.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Pedro Escoll, Carmen Buchrieser. Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?. FEBS Journal, Wiley, 2018, 285 (12), pp.2146-2160. ⟨10.1111/febs.14446⟩. ⟨pasteur-02437195⟩

Share

Metrics

Record views

62

Files downloads

76