Skip to Main content Skip to Navigation
Journal articles

Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids

Abstract : The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as "eat me" signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-02425494
Contributor : Rogerio Amino <>
Submitted on : Monday, December 30, 2019 - 3:55:28 PM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM

Identifiers

Collections

Citation

Angelika Sturm, Rogerio Amino, Claudia van de Sand, Tommy Regen, Silke Retzlaff, et al.. Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids. Science, American Association for the Advancement of Science, 2006, 313 (5791), pp.1287-1290. ⟨10.1126/science.1129720⟩. ⟨pasteur-02425494⟩

Share

Metrics

Record views

67