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Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses

Abstract : Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum. Plasmodium vivax sporozoites consist of tachysporozoites causing primary infection and bradysporozoites leading to relapses. We hypothesise that a candidate P. vivax vaccine with low efficacy against primary infection may substantially reduce transmission by preventing relapses.
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Submitted on : Monday, December 30, 2019 - 3:35:38 PM
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Michael White, Rogerio Amino, Ivo Mueller. Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses. Trends in Parasitology, 2017, 33 (4), pp.260-263. ⟨10.1016/j.pt.2016.12.011⟩. ⟨pasteur-02425470⟩

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