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Integrative structure modeling with the Integrative Modeling Platform

Abstract : Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (https://integrativemodeling.org), and demonstrate its use.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02406448
Contributor : Riccardo Pellarin <>
Submitted on : Thursday, December 12, 2019 - 10:17:18 AM
Last modification on : Monday, January 13, 2020 - 5:08:16 PM

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Benjamin Webb, Shruthi Viswanath, Massimiliano Bonomi, Riccardo Pellarin, Charles Greenberg, et al.. Integrative structure modeling with the Integrative Modeling Platform. Protein Science, Wiley, 2018, Special Issue: Special Issue on Tools for Protein Science, 27 (1), pp.245-258. ⟨10.1002/pro.3311⟩. ⟨pasteur-02406448⟩

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