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, microtubules toward the membrane (minus-end direction)??STAT5 binds on IL-7R? pY456 then is phosphorylated by pJak1·pJak3. pSTAT5 is carried in the anterograde kinesin cargo as a dimer toward the nucleus (plus-end direction) and translocates through the nuclear pore (NPC) by means of the importin/Ran-GDP system, Minimum times for each mechanism step are indicated by red arrows