The diagnosis of infectious diseases by whole genome next generation sequencing: a new era is opening

Marc Lecuit (1, 2, 3, 4, 5) , Marc Eloit (6, 7)

1 Biologie des Infections - Biology of Infection
2 UPD5 - Université Paris Descartes - Paris 5
3 Hôpital Necker - Enfants Malades [AP-HP]
4 Service des Maladies infectieuses et tropicales [CHU Necker]
5 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
6 PathoQuest
7 Découverte de Pathogènes - Pathogen Discovery

As in other medical fields, the availability of next generation sequencing (NGS) techniques is about to revolutionize diagnostics of infectious diseases. The demonstration of the microbial origin of diseases and their diagnosis were initially based on the demonstration of the presence of a given pathogen in a given clinical sample, and was first dominated by culture assay for bacteria and later for viruses [...]

Mots clés: infectious disease medicine; next-generation sequencing; bacteriology; virology; routine; diagnostic tests; microbiology

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Maladies infectieuses

Marc Lecuit, Marc Eloit. The diagnosis of infectious diseases by whole genome next generation sequencing: a new era is opening. Frontiers in Cellular and Infection Microbiology, 2014, 4, pp.25. ⟨10.3389/fcimb.2014.00025⟩. ⟨pasteur-02395735⟩