The diagnosis of infectious diseases by whole genome next generation sequencing: a new era is opening

Marc Lecuit (1, 2, 3, 4, 5) , Marc Eloit (6, 7)

1 Biologie des Infections - Biology of Infection
2 UPD5 - Université Paris Descartes - Paris 5
3 CHU Necker - Enfants Malades [AP-HP]
4 Service des Maladies infectieuses et tropicales [CHU Necker]
5 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
6 PathoQuest
7 Découverte de Pathogènes - Pathogen Discovery

As in other medical fields, the availability of next generation sequencing (NGS) techniques is about to revolutionize diagnostics of infectious diseases. The demonstration of the microbial origin of diseases and their diagnosis were initially based on the demonstration of the presence of a given pathogen in a given clinical sample, and was first dominated by culture assay for bacteria and later for viruses [...]

Keywords: infectious disease medicine; next-generation sequencing; bacteriology; virology; routine; diagnostic tests; microbiology

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Marc Lecuit, Marc Eloit. The diagnosis of infectious diseases by whole genome next generation sequencing: a new era is opening. Frontiers in Cellular and Infection Microbiology, 2014, 4, pp.25. ⟨10.3389/fcimb.2014.00025⟩. ⟨pasteur-02395735⟩