Listeria monocytogenes-Associated Biliary Tract Infections

Caroline Charlier (1, 2, 3, 4) , Cindy Fevre (2) , Laetitia Travier (2) , Benoît Cazenave (3, 1) , Hélène Bracq-Dieye (1, 3) , Juliette Podevin (5) , Daher Assomany (6) , Lydie Guilbert (6) , Céline Bossard (5) , Françoise Carpentier (6) , Valérie Cales (7) , Alexandre Leclercq (1, 3) , Marc Lecuit (2, 8, 1, 3, 9, 4)

1 CNRL - Centre National de Référence Listeria - National Reference Center Listeria
2 Biologie des Infections - Biology of Infection
3 CC-OMS / WHO-CC - Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria
4 Centre d'infectiologie Necker-Pasteur [CHU Necker]
5 CHU Nantes - Centre hospitalier universitaire de Nantes
6 Centre Hospitalier de Roubaix
7 Centre hospitalier de Pau
8 CHU Necker - Enfants Malades [AP-HP]
9 UPD5 - Université Paris Descartes - Paris 5

At present, little is known regarding Listeria mono-cytogenes-associated biliary tract infection, a rare form of listeriosis. In this article, we will study 12 culture-proven cases reported to the French National Reference Center for Listeria from 1996 to 2013 and review the 8 previously published cases. Twenty cases were studied: 17 cholecystitis, 2 cholangitis, and 1 biliary cyst infection. Half were men with a median age of 69 years (32-85). Comorbidities were present in 80%, including cirrhosis, rheumatoid arthritis, and diabetes. Five patients received immunosuppressive therapy, including cortico-steroids and anti-tumor necrosis factor biotherapies. Half were afebrile. Blood cultures were positive in 60% (3/5). Gallbladder histological lesions were analyzed in 3 patients and evidenced acute, chronic, or necrotic exacerbation of chronic infection. Genoserogroup of the 12 available strains were IVb (n ¼ 6), IIb (n ¼ 5), and IIa (n ¼ 1). Their survival in the bile was not enhanced when compared with isolates from other listeriosis cases. Adverse outcome was reported in 33% (5/15): 3 deaths, 1 recurrence; 75% of the patients with adverse outcome received inadequate antimicrobial therapy (P ¼ 0.033). Biliary tract listeriosis is a severe infection associated with high mortality in patients not treated with appropriate therapy. This study provides medical relevance to in vitro and animal studies that had shown Listeria monocytogenes ability to survive in bile and induce overt biliary infections. (Medicine 93(18):e105) Abbreviations: BHI = brain heart infusion, CNS = central nervous system, Lm = Listeria monocytogenes, MIC = minimal inhibitory concentration, MLST = multilocus sequence typing, MN = maternal-neonatal, NRCL = National Reference Center for Listeria, S = septicemia.

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Microbiology and Parasitology; Bacteriology

Caroline Charlier, Cindy Fevre, Laetitia Travier, Benoît Cazenave, Hélène Bracq-Dieye, et al.. Listeria monocytogenes-Associated Biliary Tract Infections. Medicine, 2014, 93 (18), pp.e105. ⟨10.1097/MD.0000000000000105⟩. ⟨pasteur-02391680⟩