, versity (PPU) International PhD program. This project has received funding from the CNBG Company
Ontogeny of the hematopoietic system, Annu Rev Immunol, vol.25, pp.745-85, 2007. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00362028
Transcriptional regulation of innate and adaptive lymphocyte lineages, Annu Rev Immunol, vol.33, pp.607-649, 2015. ,
The influence of developmental timing on B cell diversity, Curr Opin Immunol, vol.51, pp.7-13, 2018. ,
The development and maintenance of resident macrophages, Nat Immunol, vol.17, pp.2-8, 2016. ,
gd T cells in homeostasis and host defence of epithelial barrier tissues, Nat Rev Immunol, vol.17, pp.733-778, 2017. ,
Toward a layered immune system, Cell, vol.59, pp.953-957, 1989. ,
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors, Nature, vol.518, pp.547-51, 2015. ,
Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells, Cell Stem Cell, vol.13, pp.535-583, 2013. ,
Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential, Proc Natl Acad Sci U S A, vol.108, 2011. ,
Protective roles of natural IgM antibodies, Front Immunol, vol.3, p.66, 2012. ,
Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse, Dev Camb Engl, vol.126, pp.5073-84, 1999. ,
Circulation is established in a stepwise pattern in the mammalian embryo, Blood, vol.101, pp.1669-75, 2003. ,
Three pathways to mature macrophages in the early mouse yolk sac, Blood, vol.106, pp.3004-3015, 2005. ,
Hemogenic endothelial fate mapping reveals dual developmental origin of mast cells, Immunity, vol.48, p.5, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02024628
C-Mybþ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages, Immunity, vol.42, pp.665-78, 2015. ,
Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura, Cell, vol.86, pp.907-923, 1996. ,
Definitive hematopoiesis is autonomously initiated by the AGM region, Cell, vol.86, pp.897-906, 1996. ,
Blood stem cells emerge from aortic endothelium by a novel type of cell transition, Nature, vol.464, pp.112-117, 2010. ,
Hematopoietic stem cells derive directly from aortic endothelium during development, Nature, vol.464, pp.108-119, 2010. ,
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium, Nature, vol.464, pp.116-136, 2010. ,
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo, Nature, vol.518, pp.542-548, 2015. ,
Cell tracing shows the contribution of the yolk sac to adult haematopoiesis, Nature, vol.446, pp.1056-61, 2007. ,
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo, Nature, vol.548, pp.456-60, 2017. ,
Distinct sources of hematopoietic progenitors emerge before HSCs and provide functional blood cells in the mammalian embryo, Cell Rep, vol.11, pp.1892-904, 2015. ,
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation, Cell Stem Cell, vol.2, pp.252-63, 2008. ,
Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo, EMBO J, vol.19, pp.2465-74, 2000. ,
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs, Blood, vol.122, pp.2338-2383, 2013. ,
Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf for their development, Proc Natl Acad Sci, vol.111, pp.12151-12157, 2014. ,
Runx transcription factors in the development and function of the definitive hematopoietic system, Blood, vol.129, pp.2061-2070, 2017. ,
Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells, Exp Hematol, vol.60, pp.1-9, 2018. ,
The purification and characterization of fetal liver hematopoietic stem cells, Proc Natl Acad Sci, vol.92, pp.10302-10308, 1995. ,
Layered evolution in the immune system: a view from history: layered evolution in the immune system ,
, Ann N Y Acad Sci, vol.1362, pp.1-5, 2015.
Layered evolution in the immune system: a model for the ontogeny and development of multiple lymphocyte lineages, Ann N Y Acad Sci, vol.651, pp.1-9, 1992. ,
Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells, Blood, vol.114, pp.4960-4967, 2009. ,
Fetal hematopoietic stem cell transplantation fails to fully regenerate the B-lymphocyte compartment, Stem Cell Rep, vol.6, pp.137-186, 2016. ,
To B-1a or not to B-1a: do hematopoietic stem cells contribute to tissue-resident immune cells?, Blood, vol.128, pp.2765-2774, 2016. ,
All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells, Cell Stem Cell, vol.9, pp.64-73, 2011. ,
A transient developmental hematopoietic stem cell gives rise to innate-like B and T cells, Cell Stem Cell, vol.19, pp.768-83, 2016. ,
Identification of Flt3þ lympho-myeloid stem cells lacking erythro-megakaryocytic potential, Cell, vol.121, pp.295-306, 2005. ,
Distinct genetic networks orchestrate the emergence of specific waves of fetal and adult B-1 and B-2 development, Immunity, vol.45, pp.527-566, 2016. ,
Cellular barcoding links B-1a B cell potential to a fetal hematopoietic stem cell state at the single-cell level, Immunity, vol.45, pp.346-57, 2016. ,
Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis, Science, vol.335, pp.1195-200, 2012. ,
BCR-dependent lineage plasticity in mature B cells, Science, vol.363, pp.748-53, 2019. ,
Identification of clonogenic common lymphoid progenitors in mouse bone marrow, Cell, vol.91, pp.661-72, 1997. ,
Transcriptional control of early T and B cell developmental choices, Annu Rev Immunol, vol.32, pp.283-321, 2014. ,
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities, EMBO J, vol.15, pp.5647-58, 1996. ,
The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells, Blood, vol.104, pp.3894-900, 2004. ,
1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoidemyeloid progenitors, Immunity, vol.6, pp.437-484, 1997. ,
1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch, J Exp Med, vol.202, pp.1411-1433, 2005. ,
Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment, Science, vol.258, pp.808-820, 1992. ,
Thymopoiesis independent of common lymphoid progenitors, Nat Immunol, vol.4, pp.168-74, 2003. ,
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros, Nat Immunol, vol.9, pp.927-963, 2008. ,
Ikaros is critical for B cell differentiation and function, Eur J Immunol, vol.32, pp.720-750, 2002. ,
Failure of B-cell differentiation in mice lacking the transcription factor EBF, Nature, vol.376, pp.263-270, 1995. ,
Early B-cell factor, E2A, and pax-5 cooperate to activate the early B cell-specific mb-1 promoter, Mol Cell Biol, vol.22, pp.8539-51, 2002. ,
Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A, J Exp Med, vol.199, pp.1689-700, 2004. ,
Assembling a gene regulatory network for specification of the B cell fate, Dev Cell, vol.7, pp.607-624, 2004. ,
Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors, J Exp Med, vol.201, pp.971-980, 2005. ,
IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF, J Exp Med, vol.201, pp.1197-203, 2005. ,
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development, Genes Dev, vol.23, pp.2376-81, 2009. ,
Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity, Blood, vol.115, pp.2601-2610, 2010. ,
Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells, Nat Immunol, vol.14, pp.867-75, 2013. ,
A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation, EMBO J, vol.10, pp.3409-3426, 1991. ,
Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function, J Immunol, vol.178, pp.3031-3038, 2007. ,
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5, Nature, vol.401, pp.556-62, 1999. ,
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms, Mol Cell Biol, vol.20, pp.429-469, 2000. ,
The transcriptional regulation of B cell lineage commitment, Immunity, vol.26, pp.715-740, 2007. ,
E2A proteins are required for proper B cell development and initiation of lmmunoglobulin gene rearrangements, Cell, vol.79, pp.885-892, 1994. ,
E47 is required for V(D)J recombinase activity in common lymphoid progenitors, J Exp Med, vol.202, pp.1669-77, 2005. ,
The helix-loop-helix gene E2A is required for B cell formation, Cell, vol.79, pp.875-84, 1994. ,
Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression, J Immunol, vol.169, pp.261-70, 2002. ,
Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5, Mol Cell Biol, vol.27, pp.579-94, 2007. ,
Identification of the earliest prethymic T-cell progenitors in murine fetal blood, Blood, vol.103, pp.530-537, 2004. ,
Both E12 and E47 allow commitment to the B cell lineage, Immunity, vol.6, pp.145-54, 1997. ,
Fate mapping and quantitation of hematopoiesis in vivo, Annu Rev Immunol, vol.34, pp.449-78, 2016. ,
Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors, Immunity, vol.26, pp.407-426, 2007. ,
Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals, Immunity, vol.45, pp.597-609, 2016. ,
The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45þCD4þCD3-cells, as well As macrophages, J Immunol, vol.166, pp.6593-601, 2001. ,
Flk2þ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages, Blood, vol.111, pp.5562-70, 2008. ,
Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in flt3-negative common lymphoid progenitors, J Immunol, vol.189, pp.3822-3852, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00738937
Expression of alpha(4)beta(7) integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells, J Immunol, vol.167, pp.2511-2532, 2001. ,
Notch signaling is necessary for adult, but not fetal, development of RORgt(þ) innate lymphoid cells, Nat Immunol, vol.12, pp.949-58, 2011. ,
Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver, Nat Immunol, vol.18, pp.1139-1188, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01584003
New molecular insights into immune cell development, Annu Rev Immunol, vol.37, pp.497-519, 2019. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02118987
Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/-) mice, J Exp Med, vol.194, pp.1141-50, 2001. ,
Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment, Proc Natl Acad Sci, vol.101, pp.11070-11075, 2004. ,
Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus, Nat Immunol, vol.15, pp.27-35, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00932592