Bacterial RNA Degradosomes: Molecular Machines under Tight Control

Abstract : Bacterial RNA degradosomes are multienzyme molecular machines that act as hubs for post-transcriptional regulation of gene expression. The ribonuclease activities of these complexes require tight regulation, as they are usually essential for cell survival while potentially destructive. Recent studies have unveiled a wide variety of regulatory mechanisms including autoregulation, post-translational modifications, and protein compartmentalization. Recently, the subcellular organization of bacterial RNA degradosomes was found to present similarities with eukaryotic messenger ribonucleoprotein (mRNP) granules, membraneless compartments that are also involved in mRNA and protein storage and/or mRNA degradation. In this review, we present the current knowledge on the composition and targets of RNA degradosomes, the most recent developments regarding the regulation of these machineries, and their similarities with the eukaryotic mRNP granules.
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Submitted on : Friday, November 8, 2019 - 2:39:59 PM
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Alejandro Tejada Arranz, Valerie de Crecy-Lagard, Hilde de Reuse. Bacterial RNA Degradosomes: Molecular Machines under Tight Control. Trends in Biochemical Sciences, Elsevier, 2019, ⟨10.1016/j.tibs.2019.10.002⟩. ⟨pasteur-02355901⟩

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