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Top-Down Garbage Collector: a tool for selecting high-quality top-down proteomics mass spectra

Diogo Lima 1 André Silva 2 Mathieu Dupré 1 Marlon Santos 2 Milan Clasen 2 Louise Kurt 2 Priscila Aquino 3 Valmir C Barbosa 4 Paulo Carvalho 2, * Julia Chamot-Rooke 1, * 
* Corresponding author
1 UTechS MSBio - Spectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology
2 ICC - Fiocruz Paraná - Instituto Carlos Chagas / Carlos Chagas Institute [Curitiba, Brésil]
3 ILMD - Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil]
4 UFRJ - Universidade Federal do Rio de Janeiro
Abstract : MOTIVATION: We present the first tool for unbiased quality control of top-down proteomics datasets. Our tool can select high-quality top-down proteomics spectra, serve as a gateway for building top-down spectral libraries and, ultimately, improve identification rates. RESULTS: We demonstrate that a twofold rate increase for two E. coli top-down proteomics datasets may be achievable. AVAILABILITY AND IMPLEMENTATION: http://patternlabforproteomics.org/tdgc, freely available for academic use. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02330759
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Submitted on : Thursday, October 24, 2019 - 10:37:54 AM
Last modification on : Thursday, April 14, 2022 - 3:18:01 PM

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Diogo Lima, André Silva, Mathieu Dupré, Marlon Santos, Milan Clasen, et al.. Top-Down Garbage Collector: a tool for selecting high-quality top-down proteomics mass spectra. Bioinformatics, 2019, 35 (18), pp.3489-3490. ⟨10.1093/bioinformatics/btz085⟩. ⟨pasteur-02330759⟩

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