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Top-Down Garbage Collector: a tool for selecting high-quality top-down proteomics mass spectra

Abstract : MOTIVATION: We present the first tool for unbiased quality control of top-down proteomics datasets. Our tool can select high-quality top-down proteomics spectra, serve as a gateway for building top-down spectral libraries and, ultimately, improve identification rates. RESULTS: We demonstrate that a twofold rate increase for two E. coli top-down proteomics datasets may be achievable. AVAILABILITY AND IMPLEMENTATION: http://patternlabforproteomics.org/tdgc, freely available for academic use. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02330759
Contributor : Virginie Portelette <>
Submitted on : Thursday, October 24, 2019 - 10:37:54 AM
Last modification on : Monday, October 19, 2020 - 2:34:03 PM

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Diogo Lima, André Silva, Mathieu Dupré, Marlon Santos, Milan Clasen, et al.. Top-Down Garbage Collector: a tool for selecting high-quality top-down proteomics mass spectra. Bioinformatics, Oxford University Press (OUP), 2019, 35 (18), pp.3489-3490. ⟨10.1093/bioinformatics/btz085⟩. ⟨pasteur-02330759⟩

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