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Journal articles
Conformational sampling of CpxA: Connecting HAMP motions to the histidine kinase function
Abstract : In the histidine kinase family, the HAMP and DHp domains are considered to play an important role into the transmission of signal arising from environmental conditions to the auto-phosphorylation site and to the binding site of response regulator. Several conformational motions inside HAMP have been proposed to transmit this signal: (i) the gearbox model, (ii) α helices rotations, pistons and scissoring, (iii) transition between ordered and disordered states. In the present work, we explore by temperature-accelerated molecular dynamics (TAMD), an enhanced sampling technique, the conformational space of the cytoplasmic region of histidine kinase CpxA. Several HAMP motions, corresponding to α helices rotations , pistoning and scissoring have been detected and correlated to the segmental motions of HAMP and DHp domains of CpxA.
Cited literature [78 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02330083
Contributor : Thérèse Malliavin Connect in order to contact the contributor
Submitted on : Wednesday, October 23, 2019 - 6:11:21 PM
Last modification on : Wednesday, November 3, 2021 - 9:31:17 AM
Long-term archiving on: : Friday, January 24, 2020 - 9:06:21 PM
Contributor : Thérèse Malliavin Connect in order to contact the contributor
Submitted on : Wednesday, October 23, 2019 - 6:11:21 PM
Last modification on : Wednesday, November 3, 2021 - 9:31:17 AM
Long-term archiving on: : Friday, January 24, 2020 - 9:06:21 PM
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journal.pone.0207899.pdf
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Distributed under a Creative Commons Attribution 4.0 International License