Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells, Annu. Rev. Biochem, vol.80, p.4424, 2009. ,
Phosphatidylinositol-3-phosphate clearance plays a key role in autophagosome completion, Curr. Biol, vol.22, pp.1545-1553, 2012. ,
Recent progress in autophagic lysosome reformation, Traffic, vol.18, pp.358-361, 2017. ,
Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries, Nat Commun, vol.5, p.3207, 2014. ,
Dual role of Atg1 in regulation of autophagy-specific PAS assembly in Saccharomyces cerevisiae, Autophagy, vol.4, pp.724-726, 2008. ,
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae, Mol. Biol. Cell, vol.19, pp.668-681, 2008. ,
Atg17 regulates the magnitude of the autophagic response, Mol. Biol. Cell, vol.16, pp.3438-3453, 2005. ,
Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation, Cell, vol.163, pp.866-879, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01238262
Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery, Trends Biochem Sci, vol.42, pp.42-56, 2017. ,
Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding, Neuron, vol.33, pp.63-74, 2002. ,
The lysosome, Sci. Am, vol.208, pp.64-72, 1963. ,
ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes, Nature, vol.520, pp.563-566, 2015. ,
Mechanism and medical implications of mammalian autophagy, Nat. Rev. Mol. Cell Biol, vol.60, p.604, 2018. ,
Mobility in geometrically confined membranes, Proc. Natl. Acad. Sci. USA, vol.108, pp.12605-12610, 2011. ,
, WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12-5-16L1, vol.55, pp.238-252, 2014.
Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L), Proc. Natl. Acad. Sci. USA, vol.108, pp.7769-7774, 2011. ,
A simple method for the isolation and purification of total lipides from animal tissues, J. Biol. Chem, vol.226, pp.497-509, 1957. ,
Mechanism of cargo-directed Atg8 conjugation during selective autophagy, p.18799, 2016. ,
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure, Mol. Biol. Cell, vol.19, pp.4651-4659, 2008. ,
The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis, p.947, 2013. ,
Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment, vol.3, p.4135, 2014. ,
Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis, EMBO Rep, vol.18, pp.1586-1603, 2017. ,
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy, EMBO Rep, vol.9, pp.859-864, 2008. ,
Conformational switch of syntaxin-1 controls synaptic vesicle fusion, Science, vol.321, pp.1507-1510, 2008. ,
Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores, J. Cell Biol, vol.144, 2018. ,
ER exit sites are physical and functional core autophagosome biogenesis components, Mol. Biol. Cell, vol.24, pp.2918-2931, 2013. ,
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy, J. Biol. Chem, vol.282, pp.37298-37302, 2007. ,
Isolation and Characterization of Yeast Mutants in the Cytoplasm to Vacuole Protein Targeting Pathway, 1995. ,
, J. Cell Biol, vol.131, pp.591-602
Model cell membranes: Techniques to form complex biomimetic supported lipid bilayers via vesicle fusion, Curr Opin Colloid Interface Sci, vol.18, pp.448-458, 2013. ,
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation, Nat. Cell Biol, vol.11, pp.1433-1437, 2009. ,
Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast, J. Cell Biol, vol.175, pp.925-935, 2006. ,
Membrane fusion intermediates via directional and full assembly of the SNARE complex, Science, vol.336, pp.1581-1584, 2012. ,
Atg4 plays an important role in efficient expansion of autophagic isolation membranes by cleaving lipidated Atg8 in Saccharomyces cerevisiae, PLoS ONE, vol.12, 2017. ,
The HOPS/class C Vps complex tethers membranes by binding to one Rab GTPase in each apposed membrane, Mol. Biol. Cell, vol.26, pp.2655-2663, 2015. ,
The HOPS/Class C Vps Complex Tethers High-Curvature Membranes via a Direct Protein-Membrane Interaction, Traffic, vol.17, pp.1078-1090, 2016. ,
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy, Mol. Biol. Cell, vol.20, pp.1981-1991, 2009. ,
In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy, J. Biol. Chem, vol.279, pp.40584-40592, 2004. ,
Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis, Nat. Cell Biol, vol.19, pp.787-798, 2015. ,
Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34, Science, vol.327, pp.1638-1642, 2010. ,
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate, J. Cell. Sci, vol.116, pp.1679-1688, 2003. ,
A protein conjugation system essential for autophagy, Nature, vol.395, pp.395-398, 1998. ,
LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy. Mol Cell, vol.48, pp.329-342, 2012. ,
Formation of Large Unilamellar Vesicles by Extrusion, Liposome Technology, vol.I, pp.55-65, 2009. ,
SNARE proteins are required for macroautophagy, Cell, vol.146, pp.290-302, 2011. ,
A role for Atg8-PE deconjugation in autophagosome biogenesis, Autophagy, vol.8, pp.780-793, 2012. ,
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion, Cell, vol.130, pp.165-178, 2007. ,
Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics, FEBS J, vol.284, pp.1267-1278, 2017. ,
Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3, Nat. Cell Biol, vol.16, pp.415-424, 2014. ,
Visualization of Atg3 during autophagosome formation in Saccharomyces cerevisiae, J. Biol. Chem, vol.290, pp.8146-8153, 2015. ,
Sensing Membrane Curvature in Macroautophagy, J Mol Biol, vol.429, pp.457-472, 2017. ,
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation, J. Cell Biol, vol.215, pp.857-874, 2016. ,
Atg8-family interacting motif crucial for selective autophagy, FEBS Lett, vol.584, pp.1379-1385, 2010. ,
Membrane delivery to the yeast autophagosome from the Golgi-endosomal system, Mol. Biol. Cell, vol.21, pp.3998-4008, 2010. ,
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14, Autophagy, vol.12, pp.547-564, 2016. ,
ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction, Autophagy, vol.14, pp.584-597, 2018. ,
The specificity of SNARE-dependent fusion is encoded in the SNARE motif, Proc. Natl. Acad. Sci. USA, vol.101, pp.3376-3380, 2004. ,
A reversible phosphoswitch mediated by ULK1 regulates the activity of autophagy protease ATG4B, Nat Commun, vol.8, p.9, 2017. ,
The synaptic SNARE complex is a parallel four-stranded helical bundle, Nat. Struct. Biol, vol.5, pp.765-769, 1998. ,
WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome, J. Cell. Sci, vol.128, pp.207-217, 2015. ,
WIPI-1? (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy, Oncogene, vol.23, pp.9314-9325, 2004. ,
Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy, J. Biol. Chem, vol.291, pp.6026-6035, 2016. ,
Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis, Cell, vol.151, pp.1501-1512, 2012. ,
The Atg1-kinase complex tethers Atg9-vesicles to initiate autophagy, Nat Commun, vol.7, p.10338, 2016. ,
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy, Hum. Mol. Genet, vol.11, pp.1107-1117, 2002. ,
Recent applications of fluorescence recovery after photobleaching (FRAP) to membrane bio-macromolecules, Sensors (Basel), vol.10, pp.5927-5948, 2010. ,
Autophagosome Maturation and Fusion, J Mol Biol, vol.429, pp.486-496, 2017. ,
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts, Autophagy, vol.1, pp.101-109, 2005. ,
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae, Mol. Biol. Cell, vol.15, pp.2189-2204, 2004. ,
Increasing Diversity of Biological Membrane Fission Mechanisms, Trends Cell Biol, vol.28, pp.274-286, 2018. ,
Distinct biochemical requirements for the budding, targeting, and fusion of ER-derived transport vesicles, J. Cell Biol, vol.114, pp.219-229, 1991. ,
A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole, Mol. Biol. Cell, vol.8, pp.2307-2327, 1997. ,
New concepts for fluorescence correlation spectroscopy on membranes, Phys Chem Chem Phys, vol.10, pp.3487-3497, 2008. ,
Structural and functional analysis of the GABARAP interaction motif (GIM), EMBO Rep, vol.18, pp.1382-1396, 2017. ,
Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy, Mol Cell, vol.53, pp.167-178, 2014. ,
Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation, EMBO J, vol.31, pp.4304-4317, 2012. ,
Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation, Nat Commun, vol.8, p.295, 2017. ,
Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy, Nat. Cell Biol, vol.16, pp.425-433, 2014. ,
, , 2016.
, LC3/GABARAP family proteins: autophagy-(un)related functions, FASEB J, vol.30, pp.3961-3978
Secretory vesicle transport velocity in living cells depends on the myosin-V lever arm length, J. Cell Biol, vol.156, pp.35-39, 2002. ,
Atg17 recruits Atg9 to organize the pre-autophagosomal structure, Genes Cells, vol.14, pp.525-538, 2009. ,
Model membrane platforms to study protein-membrane interactions, Mol. Membr. Biol, vol.29, pp.144-154, 2012. ,
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway, Dev. Cell, vol.3, pp.825-837, 2002. ,
Molecular motors: Single-molecule mechanics, Curr. Biol, vol.6, pp.392-394, 1996. ,
Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16, J. Biol. Chem, vol.281, pp.3017-3024, 2006. ,
TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export, Mol Cell, vol.60, pp.89-104, 2015. ,
Helical extension of the neuronal SNARE complex into the membrane, Nature, vol.460, pp.525-528, 2009. ,
Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins, EMBO J, vol.36, pp.549-564, 2017. ,
Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components, Proc. Natl. Acad. Sci. U.S.A, vol.106, pp.17626-17633, 2009. ,
Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae, J. Cell. Sci, vol.126, pp.2534-2544, 2013. ,
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation, EMBO J, vol.20, pp.5971-5981, 2001. ,
Selective transport of alphamannosidase by autophagic pathways: identification of a novel receptor, Atg34p. J. Biol. Chem, vol.285, pp.30019-30025, 2010. ,
Hierarchy of Atg proteins in preautophagosomal structure organization, Genes Cells, vol.12, pp.209-218, 2007. ,
Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation, Proc. Natl. Acad. Sci. USA, vol.112, pp.3350-3355, 2015. ,
Force and velocity measured for single kinesin molecules, Cell, vol.77, pp.773-784, 1994. ,
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure, Nat Commun, vol.9, p.2855, 2018. ,
Cryo-electron microscopy of membrane proteins, 2018. ,
, Isolation of Autophagocytosis Mutants of Saccharomyces-Cerevisiae, 1994.
, FEBS Lett, vol.349, pp.275-280
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane, Science, vol.354, pp.1036-1041, 2016. ,
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae, FEBS Lett, vol.333, pp.169-174, 1993. ,
GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion, Proc. Natl. Acad. Sci. USA, vol.112, pp.7015-7020, 2015. ,
LC3 and GATE-16 N Termini Mediate Membrane Fusion Processes Required for Autophagosome Biogenesis, Dev. Cell, vol.20, pp.444-454, 2011. ,
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis, EMBO J, vol.29, pp.1792-1802, 2010. ,
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation, Nat Commun, vol.9, p.2932, 2018. ,
The LC3 interactome at a glance, J. Cell. Sci, vol.127, pp.3-9, 2013. ,
Reconstituting multivesicular body biogenesis with purified components, Methods Cell Biol, vol.108, pp.73-92, 2012. ,
Molecular mechanism of multivesicular body biogenesis by ESCRT complexes, Nature, vol.464, pp.864-869, 2010. ,
Membrane scission by the ESCRT-III complex, Nature, vol.458, pp.172-177, 2009. ,
Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy, vol.4, p.8941, 2015. ,
Atg8 controls phagophore expansion during autophagosome formation, Mol. Biol. Cell, vol.19, pp.3290-3298, 2008. ,
, The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes, vol.38, pp.86-99, 2016.
Atg9 vesicles are an important membrane source during early steps of autophagosome formation, J. Cell Biol, vol.198, pp.219-233, 2012. ,
Comparative genomics revealed the origin and evolution of autophagy pathway, Journal of Systematics and Evolution, vol.55, pp.71-82, 2017. ,
Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway, Mol. Biol. Cell, vol.16, pp.1593-1605, 2005. ,
, Dual roles of Atg8-PE deconjugation by Atg4 in autophagy, vol.8, pp.883-892, 2012.