Skip to Main content Skip to Navigation
Journal articles

Pathogens, microbiome and the host: emergence of the ecological Koch's postulates

Abstract : Even though tremendous progress has been made in the last decades to elucidate the mechanisms of intestinal homeostasis, dysbiosis and disease, we are only at the beginning of understanding the complexity of the gut ecosystem and the underlying interaction networks. We are also only starting to unravel the mechanisms that pathogens have evolved to overcome the barriers imposed by the microbiota and host to exploit the system to their own benefit. Recent work in these domains clearly indicates that the 'traditional Koch's postulates', which state that a given pathogen leads to a distinct disease, are not valid for all 'infectious' diseases, but that a more complete and complex interpretation of Koch's postulates is needed in order to understand and explain them. This review summarises the current understanding of what defines a healthy gut ecosystem and highlights recent progress in uncovering the interplay between the host, its microbiota and invading intestinal pathogens. Based on these recent findings, we propose a new interpretation of Koch's postulates that we term 'ecological Koch's postulates'.
Complete list of metadatas

Cited literature [309 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02305645
Contributor : Pascale Vonaesch <>
Submitted on : Friday, October 4, 2019 - 1:44:56 PM
Last modification on : Friday, October 23, 2020 - 4:44:15 PM

File

VonaeschetalFEMSReview2018.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

Citation

Pascale Vonaesch, Mark Anderson, Philippe Sansonetti. Pathogens, microbiome and the host: emergence of the ecological Koch's postulates. FEMS Microbiology Reviews, Wiley-Blackwell, 2018, 42 (3), pp.273-292. ⟨10.1093/femsre/fuy003⟩. ⟨pasteur-02305645⟩

Share

Metrics

Record views

310

Files downloads

478