Circulating interferon‐α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity: Comment on the Article by Mathian et al.

Isabelle Melki (1, 2) , Hervé Devilliers (3) , Cyril Gitiaux (4) , Vincent Bondet (5) , Alexandre Belot (6, 7) , Christine Bodemer (8, 9, 1) , Pierre Quartier (10, 1) , Yanick Crow (1) , Darragh Duffy (5) , Mathieu Rodéro (11, 12) , Brigitte Bader Meunier (10, 1)

1 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
2 AP-HP Hôpital universitaire Robert-Debré [Paris]
3 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
4 Service de neurologie pédiatrique [CHU Necker]
5 Immunobiologie des Cellules dendritiques
6 Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases
7 HFME - Hôpital Femme Mère Enfant [CHU - HCL]
8 Service de dermatologie [CHU Necker]
9 MAGEC - Centre de référence national des Maladies Génétiques à Expression Cutanée - National Reference Center for Genodermatoses and Rare Skin Diseases
10 Service d'immuno-hématologie pédiatrique [CHU Necker]
11 Equipe Inserm U1163 - Laboratory of neurogenetics and neuroinflammation
12 CBMIT - Modélisation et Immunologie pour la Thérapie

Letter to the editor We read with interest the study of Mathian et al (1), suggesting that direct serum IFNα determination with a highly sensitive assay might be useful for disease activity monitoring in systemic lupus erythematosus (SLE). More generally, the identification of reactive biomarkers is highly desirable in many disease states, including idiopathic inflammatory myositis (IIM).

Domains: Life Sciences [q-bio]; Immunology

Isabelle Melki, Hervé Devilliers, Cyril Gitiaux, Vincent Bondet, Alexandre Belot, et al.. Circulating interferon‐α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity: Comment on the Article by Mathian et al.. Arthritis & rheumatology, 2019, ⟨10.1002/art.41096⟩. ⟨pasteur-02282954⟩