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Synergistic inactivation of AXL: a (cross)road to cure ovarian cancer?

Chiara Zurzolo 1, *
* Corresponding author
Abstract : Comment on: The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer. [EMBO Rep. 2018] Inhibition of the receptor tyrosine kinase AXL, a key molecular driver of ovarian cancer, has recently been highlighted as promising therapeutic strategy. In this issue of EMBO Reports, Antony et al 1 have identified a novel mechanism of inhibition of AXL, wherein the GPI‐anchored tumour suppressor OPCML sequesters AXL into specialised plasma membrane domains where the phosphatase PTPRG is located, therefore facilitating AXL dephosphorylation. This [...]
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02263624
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Submitted on : Monday, August 5, 2019 - 1:09:08 PM
Last modification on : Friday, September 18, 2020 - 2:52:03 PM

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Chiara Zurzolo. Synergistic inactivation of AXL: a (cross)road to cure ovarian cancer?. EMBO Reports, EMBO Press, 2018, 19 (8), pp.e46492. ⟨10.15252/embr.201846492⟩. ⟨pasteur-02263624⟩

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