Skip to Main content Skip to Navigation
Journal articles

Effect of tolytoxin on tunneling nanotube formation and function

Abstract : Tunneling nanotubes (TNTs) are actin-containing membrane protrusions that play an essential role in long-range intercellular communication. They are involved in development of various diseases by allowing transfer of pathogens or protein aggregates as well as organelles such as mitochondria. Increase in TNT formation has been linked to many pathological conditions. Here we show that nM concentrations of tolytoxin, a cyanobacterial macrolide that targets actin by inhibition of its polymerization, significantly decrease the number of TNT-connected cells, as well as transfer of mitochondria and α-synuclein fibrils in two different cell lines of neuronal (SH-SY5Y) and epithelial (SW13) origin. As the cytoskeleton of the tested cell remain preserved, this macrolide could serve as a valuable tool for future therapies against diseases propagated by TNTs.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-02263619
Contributor : Reine Bouyssie <>
Submitted on : Monday, August 5, 2019 - 1:00:14 PM
Last modification on : Wednesday, October 14, 2020 - 4:15:43 AM

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Links full text

Identifiers

Collections

Citation

Aysegul Dilsizoglu Senol, Anna Pepe, Clara Grudina, Nathalie Sassoon, Ueoka Reiko, et al.. Effect of tolytoxin on tunneling nanotube formation and function. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.5741. ⟨10.1038/s41598-019-42161-6⟩. ⟨pasteur-02263619⟩

Share

Metrics

Record views

110