Molecular Phylogeny and Proposal of Two New Species of the Emerging Pathogenic Fungus Saksenaea - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Microbiology Année : 2010

Molecular Phylogeny and Proposal of Two New Species of the Emerging Pathogenic Fungus Saksenaea

Résumé

Saksenaea is a monotypic genus belonging to the order Mucorales and capable of producing severe human infections. Through a polyphasic study based on analysis of the sequences of the internal transcribed spacer (ITS) region, domains D1 and D2 of the 28S rRNA gene, and the elongation factor 1α (EF-1α) gene, as well as by evaluation of relevant morphological and physiological characteristics of a set of clinical and environmental strains, we have demonstrated that Saksenaea vasiformis is a complex of species. We propose as new species Saksenaea oblongispora, characterized by oblong sporangiospores and unable to grow at 42°C, and Saksenaea erythrospora, characterized by large sporangiophores and sporangia and by ellipsoid sporangiospores, biconcave in the lateral view. Itraconazole, posaconazole, and terbinafine were active against all isolates included in the study, while amphotericin B, voriconazole, and the echinocandins showed low activity.

Domaines

Mycologie

Dates et versions

pasteur-02263513 , version 1 (05-08-2019)

Identifiants

Citer

E. Alvarez, D. Garcia-Hermoso, D. A Sutton, J.F. Cano, A.M. Stchigel, et al.. Molecular Phylogeny and Proposal of Two New Species of the Emerging Pathogenic Fungus Saksenaea. Journal of Clinical Microbiology, 2010, 48 (12), pp.4410-4416. ⟨10.1128/JCM.01646-10⟩. ⟨pasteur-02263513⟩
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