Emergence of Disseminated Infections Due to Geosmithia argillacea in Patients with Chronic Granulomatous Disease Receiving Long-Term Azole Antifungal Prophylaxis

Marie Machouart (1, 2) , Dea Garcia-Hermoso (3) , Alexandre Rivier (2) , Noura Hassouni (4, 5) , Emilie Catherinot (4, 6) , Alexandra Salmon (2) , Anne Debourgogne (1, 2) , Hélène Coignard (4, 6) , Marc Lecuit (4, 5, 6) , Marie-Elisabeth E Bougnoux (4, 5) , Stéphane Blanche (4, 5) , Olivier Lortholary (5, 4, 3)

1 RHEM - Relations Hôte-Environnement
2 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
3 CNRMA - Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire
4 UPD5 - Université Paris Descartes - Paris 5
5 CHU Necker - Enfants Malades [AP-HP]
6 Centre d'infectiologie Necker-Pasteur [CHU Necker]

We report two cases of invasive infections due to Geosmithia argillacea, an emerging mold, in patients with chronic granulomatous disease receiving prolonged azole antifungal prophylaxis. One patient died despite receiving a combination of four antifungals, and the other developed cerebral and medullary lesions under a combination of caspofungin, posaconazole, terbinafine, and gamma interferon.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Mycology

Marie Machouart, Dea Garcia-Hermoso, Alexandre Rivier, Noura Hassouni, Emilie Catherinot, et al.. Emergence of Disseminated Infections Due to Geosmithia argillacea in Patients with Chronic Granulomatous Disease Receiving Long-Term Azole Antifungal Prophylaxis. Journal of Clinical Microbiology, 2011, 49 (4), pp.1681-1683. ⟨10.1128/JCM.02456-10⟩. ⟨pasteur-02262537⟩