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Breakthrough Hormographiella aspergillata Infections Arising in Neutropenic Patients Treated Empirically with Caspofungin

Abstract : Hormographiella aspergillata, a filamentous basidiomycete, has rarely been involved in human infections. We describe 2 febrile neutropenic patients who developed a severe pulmonary infection due to H. aspergillata while receiving empirical caspofungin therapy for presumed fungal pneumonia. After introduction of liposomal amphotericin B, one patient, who had neutrophil recovery, presented a favorable outcome, while the other, who remained neutropenic throughout the course of infection, died. Resistant fungi, including basidiomycetes, may emerge during empirical treatment with caspofungin in febrile neutropenic patients. A rapid switch to any other potent antifungal should be rapidly considered in case of failure of caspofungin in this setting.
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Submitted on : Friday, August 2, 2019 - 3:16:49 PM
Last modification on : Friday, March 27, 2020 - 2:38:16 AM

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Felipe Suarez, Olivier Olivier, Dea Garcia-Hermoso, Edouard Randriamalala, David Ghez, et al.. Breakthrough Hormographiella aspergillata Infections Arising in Neutropenic Patients Treated Empirically with Caspofungin. Journal of Clinical Microbiology, American Society for Microbiology, In press, 49 (1), pp.461-465. ⟨10.1128/JCM.01213-10⟩. ⟨pasteur-02262452⟩

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