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Breakthrough Hormographiella aspergillata Infections Arising in Neutropenic Patients Treated Empirically with Caspofungin

Abstract : Hormographiella aspergillata, a filamentous basidiomycete, has rarely been involved in human infections. We describe 2 febrile neutropenic patients who developed a severe pulmonary infection due to H. aspergillata while receiving empirical caspofungin therapy for presumed fungal pneumonia. After introduction of liposomal amphotericin B, one patient, who had neutrophil recovery, presented a favorable outcome, while the other, who remained neutropenic throughout the course of infection, died. Resistant fungi, including basidiomycetes, may emerge during empirical treatment with caspofungin in febrile neutropenic patients. A rapid switch to any other potent antifungal should be rapidly considered in case of failure of caspofungin in this setting.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02262452
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Submitted on : Friday, August 2, 2019 - 3:16:49 PM
Last modification on : Thursday, October 20, 2022 - 3:10:07 PM

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Felipe Suarez, Olivier Olivier, Dea Garcia-Hermoso, Edouard Randriamalala, David Ghez, et al.. Breakthrough Hormographiella aspergillata Infections Arising in Neutropenic Patients Treated Empirically with Caspofungin. Journal of Clinical Microbiology, In press, 49 (1), pp.461-465. ⟨10.1128/JCM.01213-10⟩. ⟨pasteur-02262452⟩

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