Imported African Histoplasmosis in an Immunocompetent Patient 40 Years after Staying in a Disease-Endemic Area

Clémence Richaud (1, 2, 3) , Marie-Olivia Chandesris (1, 3) , Fanny Lanternier (1, 2, 3, 4, 5) , Hélène Benzaquen-Forner (6) , Dea Garcia-Hermoso (4, 5) , Capucine Picard (7, 1, 2, 8) , Emilie Catherinot (1, 2, 3) , Marie-Elisabeth Bougnoux (1, 2, 3) , Olivier Lortholary (4, 5, 1, 2, 9)

1 UPD5 - Université Paris Descartes - Paris 5
2 USPC - Université Sorbonne Paris Cité
3 CHU Necker - Enfants Malades [AP-HP]
4 Mycologie moléculaire - Molecular Mycology
5 CNRMA - Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals
6 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
7 Centre d'étude des Déficits Immunitaires
8 INSERM - Institut National de la Santé et de la Recherche Médicale
9 Centre d'infectiologie Necker-Pasteur [CHU Necker]

Histoplasmosis caused by Histoplasma capsulatum var. duboisii is a rare disease outside central and western Africa. In Europe, all cases are imported. We report a case of an African histoplasmosis with isolated pulmonary involvement in a non-immunocompromised patient that occurred 40 years after his stay in a disease-endemic area. The patient was given itraconazole. (18)F-fluoro-2-deoxy-d-glucose positron emission tomography-computed tomography was used to assess evolution during treatment. The outcome for the patient was favorable.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Mycology

Clémence Richaud, Marie-Olivia Chandesris, Fanny Lanternier, Hélène Benzaquen-Forner, Dea Garcia-Hermoso, et al.. Imported African Histoplasmosis in an Immunocompetent Patient 40 Years after Staying in a Disease-Endemic Area. American Journal of Tropical Medicine and Hygiene, 2014, 91 (5), pp.1011-1014. ⟨10.4269/ajtmh.13-0731⟩. ⟨pasteur-02242455⟩