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Kératites fongiques : étude rétrospective monocentrique sur 5 ans à l’île de la Réunion

Abstract : Objectives Fungal keratitis is rare in France, but could be a severe sight-threatening condition. Here, we aimed to describe the epidemiology of fungal keratitis in Réunion Island. Methods In a retrospective study, we analyzed 13 culture-proven keratitis episodes, occurred between January 2013 and July 2017 in the ophthalmology ward of a University Hospital, Saint-Pierre. Twelve isolates were genotyped and antifungal susceptibility testing was performed. Results Corneal abrasion caused by vegetable matter was the main predisposing factor. Stromal infiltration was observed in 12 patients. Six patients did not response to medical treatment, requiring surgical care, including two enucleations surgery. Fusarium solani (n = 6) and Fusarium dimerum (n = 4) were the main fungal species involved in fungal keratitis. Clinical failures were more prevalent with F. solani infections. The lowest minimal inhibitory concentrations for Fusarium sp. were observed with voriconazole and amphotericin B. Conclusion In Reunion Island, the epidemiology of fungal keratitis is characterized by the predominance of Fusarium species, potentially involved in visual loss. This pattern is consistent with the epidemiology usually observed in tropical areas.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02193234
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Submitted on : Wednesday, July 24, 2019 - 12:20:15 PM
Last modification on : Monday, January 13, 2020 - 5:08:19 PM

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G. Hoarau, M. Albrieux, T. Martin-Phipps, K. Zitte-Zehler, L. Borry, et al.. Kératites fongiques : étude rétrospective monocentrique sur 5 ans à l’île de la Réunion. Journal Français D'Ophtalmologie, Elsevier Masson, 2018, 41 (4), pp.321-325. ⟨10.1016/j.jfo.2017.09.015⟩. ⟨pasteur-02193234⟩

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