Miltefosine-based regimen as salvage therapy in Lomentospora prolificans bone and joint infection

L. Quaesaet; E. Stindel; F. Lanternier; T. Williams; S. Jaffuel; E. Moalic; D. Garcia Hermoso; O. Lortholary; S. Ansart

doi:10.1016/j.medmal.2017.10.005

Journal articles

Miltefosine-based regimen as salvage therapy in Lomentospora prolificans bone and joint infection

L. Quaesaet ^{1, *} E. Stindel ¹ F. Lanternier ^{2, 3, 4, 5, 6} T. Williams ¹ S. Jaffuel ¹ E. Moalic ¹ D. Garcia Hermoso ^{4, 5, 3} O. Lortholary ^{7, 8, 3} S. Ansart ¹

* Corresponding author

1 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest

2 CHU Necker - Enfants Malades [AP-HP]

3 UPD5 - Université Paris Descartes - Paris 5

4 CNRMA - Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals

5 Mycologie moléculaire

6 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)

7 Centre d'infectiologie Necker-Pasteur [CHU Necker]

8 Institut Pasteur [Paris]

Abstract : 1. Introduction We report the second case of miltefosine, terbinafine, and voriconazole-based regimen as salvage therapy in a Lomentospora prolificans bone and joint infection. A favorable outcome was observed when combined with aggressive surgery. A poor prior evolution was observed following three surgical procedures of debridement combined with terbinafine and voriconazole. This report of a safe and successful use of miltefosine highlights the need for an interdisciplinary expertise for appropriate surgical and medical treatment.

Keywords : Lomentospora prolificans Infection ostéoarticulaire Bone and joint infection Miltéfosine

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Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Mycology

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Miltefosine-based regimen as salvage therapy in Lomentospora prolificans bone and joint infection

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Miltefosine-based regimen as salvage therapy in Lomentospora prolificans bone and joint infection

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