The location of a closed channel gate in the GABA A receptor channel, J Gen Physiol, vol.129, pp.145-159, 2007. ,
A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor, Phys Biol, vol.3, pp.147-159, 2006. ,
Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel, Nature, vol.430, pp.896-900, 2004. ,
A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family, Nature, vol.445, pp.116-119, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00122527
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation, Nature, vol.457, pp.111-114, 2009. ,
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors, Nature, vol.411, pp.269-276, 2001. ,
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures, Neuron, vol.41, pp.907-914, 2004. ,
, Allosteric mechanisms of signal transduction, Changeux J & Edelstein SJ, vol.308, pp.1424-1428, 2005.
Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors, PLoS Comput Biol, vol.2, p.134, 2006. ,
Mutational analysis of the charge selectivity filter of the ?7 nicotinic acetylcholine receptor, Neuron, vol.22, pp.831-843, 1999. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01718442
Nicotinic receptors at the amino acid level, Annu Rev Pharmacol Toxicol, vol.40, pp.431-458, 2000. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01719004
An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics, Biophys J, vol.90, pp.799-810, 2006. ,
Probing ion-channel pores one proton at a time, Nature, vol.438, pp.975-980, 2005. ,
A lipid-dependent uncoupled conformation of the acetylcholine receptor, J Biol Chem, vol.284, pp.17819-17825, 2009. ,
Crystal structure of the extracellular domain of nAChR a1 bound to a-bungarotoxin at 1.94 A resolution, Nat Neurosci, vol.10, pp.953-962, 2007. ,
Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic, Nature, vol.359, pp.500-505, 1992. ,
Mechanism of differential control of NMDA receptor activity by NR2 subunits, Nature, vol.459, pp.703-707, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-01145441
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labelled by [ 3 H]chlorpromazine, Proc Natl Acad Sci U S A, vol.83, pp.2719-2723, 1986. ,
Conversion of the ion selectivity of the 5-HT 3a receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily, J Biol Chem, vol.276, pp.10977-10983, 2001. ,
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations, EMBO J, vol.24, pp.3635-3646, 2005. ,
An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance, J Biol Chem, vol.283, pp.36066-36070, 2008. ,
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal a7 nicotinic acetylcholine receptor, EMBO J, vol.28, pp.3040-3051, 2009. ,
X-ray structure of a prokaryotic pentameric ligand-gated ion channel, Nature, vol.452, pp.375-379, 2008. ,
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel, Nature, vol.457, pp.115-118, 2009. ,
Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop, J Gen Physiol, vol.131, pp.137-146, 2008. ,
, J Physiol, vol.588
Mutational studies using a cation-conducting GABAA receptor reveal the selectivity determinants of the Cys-loop family of ligand-gated ion channels, J Neurochem, vol.92, pp.962-972, 2005. ,
Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity, FEBS J, vol.274, pp.3799-3845, 2007. ,
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors, Nature, vol.424, pp.321-324, 2003. ,
, , 2004.
, Ligand-gated ion channels: mechanisms underlying ion selectivity, Prog Biophys Mol Biol, vol.86, pp.161-204
Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family, J Am Chem Soc, vol.129, pp.8217-8224, 2007. ,
Expression of membrane proteins from Mycobacterium tuberculosis in Escherichia coli as fusions with maltose binding protein, Protein Expr Purif, vol.53, pp.24-30, 2007. ,
Structure and gating mechanism of the acetylcholine receptor pore, Nature, vol.423, pp.949-955, 2003. ,
Modulation of nicotinic acetylcholine receptor conformational state by free fatty acids and steroids, J Biol Chem, vol.283, pp.21478-21486, 2008. ,
Pore conformations and gating mechanism of a Cys-loop receptor, Proc Natl Acad Sci U S A, vol.102, pp.15877-15882, 2005. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00162520
Evidence for a centrally located gate in the pore of a serotonin-gated ion channel, J Neurosci, vol.22, pp.1629-1639, 2002. ,
, , 1991.
, Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor, Nature, vol.353, pp.846-849
, Recent advances in Cys-loop receptor structure and function, Nature, vol.440, pp.448-455, 2006.
A glia-derived acetylcholine-binding protein that modulates synaptic transmission, Sixma TK & Geraerts WP, vol.411, pp.261-268, 2001. ,
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism, Biophys J, vol.88, pp.3954-3965, 2005. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00162514
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system, Nat Rev Drug Discov, vol.8, pp.733-750, 2009. ,
Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels, Genome Biol, vol.6, p.4, 2005. ,
Refined structure of the nicotinic acetylcholine receptor at 4A resolution, J Mol Biol, vol.346, pp.967-989, 2005. ,
The location of the gate in the acetylcholine receptor channel, Neuron, vol.20, pp.1269-1281, 1998. ,
Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method, Proc Natl Acad Sci U S A, vol.98, pp.1241-1248, 2001. ,