Disseminated Spiroplasma apis Infection in Patient with Agammaglobulinemia, France

Nicolas Etienne (1) , Laurent Bret (2) , Cécile Le Brun (3) , Hervé Lécuyer (1) , Josquin Moraly , Fanny Lanternier (1) , Olivier Hermine (1) , Agnès Ferroni (1) , Marc Lecuit (1, 4) , Sabine Pereyre (5) , Laure Beven (5) , Olivier Lortholary (1)

1 UPD5 Médecine - Université Paris Descartes - Faculté de Médecine
2 CHRO - Centre Hospitalier Régional d'Orléans
3 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
4 IP - Institut Pasteur [Paris]
5 UB - Université de Bordeaux

We report a disseminated infection caused by Spiroplasma apis, a honeybee pathogen, in a patient in France who had X-linked agammaglobulinemia. Identification was challenging because initial bacterial cultures and direct examination by Gram staining were negative. Unexplained sepsis in patients with agammaglobulinemia warrants specific investigation to identify fastidious bacteria such as Spiroplasma spp

Keywords: Apis; immunocompromised patient; bee; btk; bruton thyrosine kinase; endocarditis; agammaglobulinemia; Spiroplasma apis; Bruton; Apis mellifera; bacteria; bacterial endocarditis; bacterial infection; genetic diseases; hypogammaglobulinemia; hornet; immunocompromised; infective endocarditis; mycoplasma; insect stings; x linked agammaglobulinemia; vector-borne infections; septic arthritis; France; Spiroplasma

Domains: Infectious diseases; Emerging diseases; Bacteriology

Nicolas Etienne, Laurent Bret, Cécile Le Brun, Hervé Lécuyer, Josquin Moraly, et al.. Disseminated Spiroplasma apis Infection in Patient with Agammaglobulinemia, France. Emerging Infectious Diseases, 2018, 24 (12), pp.2382-2386. ⟨10.3201/eid2412.180567⟩. ⟨pasteur-02139189⟩