D. Baud, D. J. Gubler, B. Schaub, M. C. Lanteri, and D. Musso, An update on Zika virus infection, Lancet, vol.390, issue.17, pp.31450-31452, 2017.

T. M. Bell, E. J. Field, and H. K. Narang, Zika virus infection of the central nervous system of mice, Arch. Gesamte Virusforsch, vol.35, pp.183-193, 1971.

A. B. Blazquez, E. Escribano-romero, T. Merino-ramos, J. C. Saiz, and M. A. Martinacebes, Stress responses in flavivirus-infected cells: activation of unfolded protein response and autophagy, Front. Microbiol, vol.5, p.266, 2014.

I. I. Bogoch, O. J. Brady, M. U. Kraemer, M. German, M. I. Creatore et al., Anticipating the international spread of Zika virus from Brazil, Lancet, vol.387, pp.335-336, 2016.

G. S. Campos, A. C. Bandeira, and S. I. Sardi, Zika virus outbreak, vol.21, pp.1885-1886, 2015.

B. Cao, M. S. Diamond, and I. U. Mysorekar, Maternal-fetal transmission of Zika Virus: routes and signals for infection, J Interferon Cytokine Res, vol.37, pp.287-294, 2017.

V. M. Cao-lormeau, A. Blake, S. Mons, S. Lastere, C. Roche et al., Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study, Lancet, vol.387, issue.16, pp.562-568, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01453407

R. J. Caswell and K. Manavi, Emerging sexually transmitted viral infections: 2. Review of Zika virus disease, Int. J. Std. Aids, vol.1, p.956462418779465, 2018.

C. Charlier, M. C. Beaudoin, T. Couderc, O. Lortholary, and M. Lecuit, Arboviruses and pregnancy: maternal, fetal, and neonatal effects, Lancet Child Adolesc. Health, vol.1, pp.134-146, 2017.

V. Chaudhary, K. S. Yuen, J. F. Chan, C. P. Chan, P. H. Wang et al., Selective activation of type II interferon signaling by Zika Virus NS5 Protein, J. Virol, vol.91, pp.163-180, 2017.

A. V. Coelho and S. Crovella, Microcephaly prevalence in infants born to Zika Virus-infected women: a systematic review and meta-analysis, Int J Mol Sci, vol.18, p.1714, 2017.

M. Cortese, S. Goellner, E. G. Acosta, C. J. Neufeldt, O. Oleksiuk et al., Ultrastructural characterization of Zika Virus replication factories. Cell Rep, vol.18, pp.2113-2123, 2017.
URL : https://hal.archives-ouvertes.fr/pasteur-01535196

M. J. Counotte, C. R. Kim, J. Wang, K. Bernstein, C. D. Deal et al., Sexual transmission of Zika virus and other flaviviruses: a living systematic review, PLoS Med, vol.15, p.1002611, 2018.

B. C. Cross, P. J. Bond, P. G. Sadowski, B. K. Jha, J. Zak et al., The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule, Proc. Natl. Acad. Sci. U.S.A, vol.109, pp.869-878, 2012.

F. R. Cugola, I. R. Fernandes, F. B. Russo, B. C. Freitas, J. L. Dias et al., The Brazilian Zika virus strain causes birth defects in experimental models, Nature, vol.534, pp.267-271, 2016.

P. Devhare, K. Meyer, R. Steele, R. B. Ray, and R. Ray, Zika virus infection dysregulates human neural stem cell growth and inhibits differentiation into neuroprogenitor cells, Cell Death Dis, vol.8, p.3106, 2017.

G. W. Dick, S. F. Kitchen, and A. J. Haddow, Zika virus. I. Isolations and serological specificity, Trans. R. Soc. Trop. Med. Hygiene, vol.46, pp.509-520, 1952.

F. Diop, T. Vial, P. Ferraris, S. Wichit, M. Bengue et al., Zika virus infection modulates the metabolomic profile of microglial cells, PLoS One, vol.13, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01921864

M. R. Duffy, T. H. Chen, W. T. Hancock, A. M. Powers, J. L. Kool et al., Zika virus outbreak on Yap Island, Federated States of Micronesia, N. Engl. J. Med, vol.360, pp.2536-2543, 2009.
URL : https://hal.archives-ouvertes.fr/pasteur-00734543

J. Dugas-ford and C. W. Ragsdale, Levels of homology and the problem of neocortex, Annu. Rev. Neurosci, vol.38, pp.351-368, 2015.

T. L. Franca, W. R. Medeiros, N. L. Souza, E. Longo, S. A. Pereira et al., Growth and development of children with microcephaly associated with congenital Zika Virus Syndrome in Brazil, Int. J. Environ. Res. Public Health, vol.15, 1990.

A. Galmiche, C. Sauzay, E. Chevet, and O. Pluquet, Role of the unfolded protein response in tumor cell characteristics and cancer outcome, Curr. Opin. Oncol, vol.29, pp.41-47, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01436298

P. P. Garcez, J. M. Nascimento, J. M. De-vasconcelos, R. Madeiro-da-costa, R. Delvecchio et al., Zika virus disrupts molecular fingerprinting of human neurospheres, Sci. Rep, vol.7, p.40780, 2017.

P. P. Garcez, H. B. Stolp, S. Sravanam, R. R. Christoff, J. Ferreira et al., Zika virus impairs the development of blood vessels in a mouse model of congenital infection, Sci. Rep, vol.8, p.12774, 2018.

D. Ghosh and A. Basu, Japanese encephalitis-a pathological and clinical perspective, PLoS Negl. Trop. Dis, vol.3, p.437, 2009.
DOI : 10.1371/journal.pntd.0000437
URL : https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000437&type=printable

V. E. Ghouzzi, F. T. Bianchi, I. Molineris, B. C. Mounce, G. E. Berto et al., ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly, Cell Death Dis, vol.7, p.2440, 2016.

I. Gladwyn-ng, L. Cordon-barris, C. Alfano, C. Creppe, T. Couderc et al., Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly, Nat. Neurosci, vol.21, pp.63-71, 2018.
DOI : 10.1038/s41593-017-0038-4
URL : https://hal.archives-ouvertes.fr/pasteur-01741181

J. D. Godin, C. Creppe, S. Laguesse, and L. Nguyen, Emerging roles for the unfolded protein response in the developing nervous system, Trends Neurosci, vol.39, pp.394-404, 2016.

J. Grootjans, A. Kaser, R. J. Kaufman, and R. S. Blumberg, The unfolded protein response in immunity and inflammation, Nat. Rev. Immunol, vol.16, pp.469-484, 2016.

J. Guadagno, X. Xu, M. Karajgikar, A. Brown, and S. P. Cregan, , 2013.

, Microglia-derived TNFalpha induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma, Cell Death Dis, vol.4, p.538

S. Gurumayum, R. Brahma, L. D. Naorem, M. Muthaiyan, J. Gopal et al., ZikaBase: an integrated ZIKV-human interactome Map database, Virology, vol.514, pp.203-210, 2018.

U. K. Hanisch, Microglia as a source and target of cytokines, Glia, vol.40, pp.140-155, 2002.

K. Himmelsbach and E. Hildt, Identification of various cell culture models for the study of Zika virus, World J. Virol, vol.7, pp.10-20, 2018.

T. Hosoi, M. Honda, T. Oba, and K. Ozawa, ER stress upregulated PGE(2)/IFNgamma-induced IL-6 expression and down-regulated iNOS expression in glial cells, Sci. Rep, vol.3, p.3388, 2013.

H. Huang, S. Li, Y. Zhang, X. Han, B. Jia et al., CD8(+) T cell immune response in immunocompetent mice during Zika Virus infection, J. Virol, vol.15, p.91, 2017.

K. A. Jurado, L. J. Yockey, P. W. Wong, S. Lee, A. J. Huttner et al., Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice, Nat. Microbiol, vol.3, pp.141-147, 2018.

D. Kamimura and M. J. Bevan, Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection, J. Immunol, vol.181, pp.5433-5441, 2008.

S. Kim, Y. Joe, H. J. Kim, Y. S. Kim, S. O. Jeong et al., Endoplasmic reticulum stress-induced IRE1alpha activation mediates crosstalk of GSK-3beta and XBP-1 to regulate inflammatory cytokine production, J. Immunol, vol.194, pp.4498-4506, 2015.

R. A. Kozak, A. Majer, M. J. Biondi, S. J. Medina, L. W. Goneau et al., MicroRNA and mRNA dysregulation in astrocytes infected with Zika Virus, Viruses, vol.9, p.297, 2017.

D. B. Kum, N. Mishra, R. Boudewijns, I. Gladwyn-ng, C. Alfano et al., A yellow fever-Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice, NPJ Vaccines, vol.3, p.56, 2018.

S. Laguesse, C. Creppe, D. D. Nedialkova, P. P. Prevot, L. Borgs et al., A dynamic unfolded protein response contributes to the control of cortical neurogenesis, Dev. Cell, vol.35, pp.553-567, 2015.

S. Laguesse, E. Peyre, and L. Nguyen, Progenitor genealogy in the developing cerebral cortex, Cell Tissue Res, vol.359, pp.17-32, 2015.

R. S. Lanciotti, O. L. Kosoy, J. J. Laven, J. O. Velez, A. J. Lambert et al., Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, Emerg. Infect. Dis, vol.14, pp.1232-1239, 2007.

Y. J. Lee, T. J. Won, K. E. Hyung, Y. W. Jang, S. J. Kim et al., IL-6 induced proliferation and cytotoxic activity of CD8(+) T cells is elevated by SUMO2 overexpression, Arch. Pharm. Res, vol.39, pp.705-712, 2016.

C. Li, D. Xu, Q. Ye, S. Hong, Y. Jiang et al., Zika virus disrupts neural progenitor development and leads to microcephaly in mice, Cell Stem Cell, vol.19, pp.120-126, 2016.

Y. Liang, T. Zhou, Y. Chen, D. Lin, X. Jing et al., Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy, Neurotoxicology, vol.63, pp.137-145, 2017.

D. Limonta, J. Jovel, A. Kumar, A. M. Airo, S. Hou et al., Human fetal astrocytes infected with Zika Virus exhibit delayed apoptosis and resistance to interferon: implications for persistence, Viruses, vol.10, p.646, 2018.

W. C. Lin, Y. C. Chuang, Y. S. Chang, M. D. Lai, Y. N. Teng et al., Endoplasmic reticulum stress stimulates p53 expression through NF-kappaB activation, PLoS One, vol.7, p.39120, 2012.

J. Liu, Q. Li, X. Li, Z. Qiu, A. Li et al., Zika Virus envelope protein induces G2/M cell cycle arrest and apoptosis via an intrinsic cell death signaling pathway in neuroendocrine PC12 cells, Int. J. Biol. Sci, vol.14, pp.1099-1108, 2018.

F. M. Lum, D. K. Low, Y. Fan, J. J. Tan, B. Lee et al., Zika Virus infects human fetal brain microglia and induces inflammation, Clin. Infect. Dis, vol.64, pp.914-920, 2017.

S. Lunardi, S. Y. Lim, R. J. Muschel, and T. B. Brunner, IP-10/CXCL10 attracts regulatory T cells: implication for pancreatic cancer, Oncoimmunology, vol.4, p.1027473, 2015.

M. Manangeeswaran, D. D. Ireland, and D. Verthelyi, Zika (PRVABC59) infection is associated with T cell infiltration and neurodegeneration in CNS of immunocompetent neonatal C57Bl/6 mice, PLoS Pathog, vol.12, p.1006004, 2016.

G. Matusali, L. Houzet, A. P. Satie, D. Mahe, F. Aubry et al., Zika virus infects human testicular tissue and germ cells, J. Clin. Invest, vol.128, pp.4697-4710, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-01868794

M. Mavigner, J. Raper, Z. Kovacs-balint, S. Gumber, J. T. O'neal et al., Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques, Sci. Trans. Med, vol.10, p.6975, 2018.

M. Mccarthy, Severe eye damage in infants with microcephaly is presumed to be due to Zika virus, BMJ, vol.352, p.855, 2016.

G. P. Meares, Y. Liu, R. Rajbhandari, H. Qin, S. E. Nozell et al., PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation, Mol. Cell Biol, vol.34, pp.3911-3925, 2014.

L. Meertens, A. Labeau, O. Dejarnac, S. Cipriani, L. Sinigaglia et al., Axl mediates ZIKA Virus entry in human glial cells and modulates innate immune responses. Cell Rep, vol.18, pp.324-333, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02013511

B. Monel, A. A. Compton, T. Bruel, S. Amraoui, J. Burlaud-gaillard et al., Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells, EMBO J, vol.36, pp.1653-1668, 2017.

C. A. Moore, J. E. Staples, W. B. Dobyns, A. Pessoa, C. V. Ventura et al., Characterizing the pattern of anomalies in congenital zika syndrome for pediatric clinicians, JAMA Pediatr, vol.171, pp.288-295, 2017.

J. A. Moreno, M. Halliday, C. Molloy, H. Radford, N. Verity et al., Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice, Sci. Trans. Med, vol.5, pp.206-138, 2013.

D. Musso and D. J. Gubler, Zika Virus, Clin. Microbiol. Rev, vol.29, pp.487-524, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01521256

E. M. Netto, A. Moreira-soto, C. Pedroso, C. Hoser, S. Funk et al., High zika virus seroprevalence in salvador, northeastern brazil limits the potential for further outbreaks, vol.8, pp.1390-1407, 2017.

E. Oehler, L. Watrin, P. Larre, I. Leparc-goffart, S. Lastere et al., Zika virus infection complicated by guillain-barre syndrome-case report, Euro Surveill, vol.19, p.20720, 2013.

I. G. Olmo, T. G. Carvalho, V. V. Costa, J. Alves-silva, C. Z. Ferrari et al., Zika Virus promotes neuronal cell death in a non-cell autonomous manner by triggering the release of neurotoxic factors, Front. Immunol, vol.8, p.1016, 2017.

J. J. O'shea and R. Plenge, JAK and STAT signaling molecules in immunoregulation and immune-mediated disease, Immunity, vol.36, pp.542-550, 2012.

A. Peloggia, M. Ali, K. Nanda, and L. Bahamondes, Zika virus exposure in pregnancy and its association with newborn visual anomalies and hearing loss, Int. J. Gynaecol. Obstet, vol.143, pp.277-281, 2018.

L. Qin, Z. Wang, L. Tao, W. , and Y. , ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy, Autophagy, vol.6, pp.239-247, 2010.

H. Radford, J. A. Moreno, N. Verity, M. Halliday, and G. R. Mallucci, PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia, Acta Neuropathol, vol.130, pp.633-642, 2015.

R. B. Richardson, M. B. Ohlson, J. L. Eitson, A. Kumar, M. B. Mcdougal et al., A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication, Nat. Microbiol, vol.3, pp.1214-1223, 2018.

A. J. Rolfe, D. B. Bosco, J. Wang, R. S. Nowakowski, J. Fan et al., Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cells, Cell Biosci, vol.6, p.42, 2016.

H. A. Rothan, S. Fang, M. Mahesh, and S. N. Byrareddy, Zika virus and the metabolism of neuronal cells, Mol. Neurobiol, 2018.

J. C. Saiz, M. A. Martin-acebes, R. Bueno-mari, O. D. Salomon, L. C. Villamiljimenez et al., Zika Virus: what have we learnt since the start of the recent epidemic?, Front. Microbiol, vol.8, p.1554, 2017.

H. Sakkas, P. Bozidis, X. Giannakopoulos, N. Sofikitis, and C. Papadopoulou, An update on sexual transmission of Zika Virus, Pathogens, vol.7, p.66, 2018.

B. Schaub, M. Gueneret, E. Jolivet, V. Decatrelle, S. Yazza et al., Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series, Lancet Child Adolesc. Health, vol.1, issue.17, pp.30001-30010, 2017.

B. Schaub, M. Vouga, F. Najioullah, M. Gueneret, A. Monthieux et al., Analysis of blood from Zika virus-infected fetuses: a prospective case series, Lancet Infect. Dis, vol.17, pp.520-527, 2017.

W. Scheper and J. J. Hoozemans, The unfolded protein response in neurodegenerative diseases: a neuropathological perspective, Acta Neuropathol, vol.130, pp.315-331, 2015.

J. A. Smith, A new paradigm: innate immune sensing of viruses via the unfolded protein response, Front. Microbiol, vol.5, p.222, 2014.

J. A. Smith, Regulation of cytokine production by the unfolded protein response; implications for infection and autoimmunity, Front. Immunol, vol.9, p.422, 2018.

N. T. Sprenkle, S. G. Sims, C. L. Sanchez, and G. P. Meares, Endoplasmic reticulum stress and inflammation in the central nervous system, Mol. Neurodegener, vol.12, p.42, 2017.

M. Stefanik, P. Formanova, T. Bily, M. Vancova, L. Eyer et al., Characterisation of Zika virus infection in primary human astrocytes, BMC Neurosci, vol.19, p.5, 2018.

L. Subissi, T. Dub, M. Besnard, T. Mariteragi-helle, T. Nhan et al., Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, vol.24, pp.1850-1858, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02004011

H. M. Ta, T. M. Le, H. Ishii, M. Takarada-iemata, T. Hattori et al., Atf6alpha deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis, J. Neurochem, vol.139, pp.1124-1137, 2016.

Z. Tan, W. Zhang, J. Sun, Z. Fu, X. Ke et al., ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells, J. Neuroinflammation, vol.15, p.275, 2018.

H. Tang, C. Hammack, S. C. Ogden, Z. Wen, X. Qian et al., Zika virus infects human cortical neural progenitors and attenuates their growth, Cell Stem Cell, vol.18, pp.587-590, 2016.

A. H. Tuttle, V. M. Philip, E. J. Chesler, and J. S. Mogil, Comparing phenotypic variation between inbred and outbred mice, Nat. Methods, vol.15, pp.994-996, 2018.

M. Y. Valdespino-vazquez, E. E. Sevilla-reyes, R. Lira, M. Yocupicio-monroy, E. Piten-isidro et al., Congenital Zika syndrome and extra-CNS detection of Zika virus in a pre-term newborn in Mexico, Clin. Infect. Dis, 2018.

H. Van-der-linden, M. D. Carvalho, V. Van-der-linden, K. M. Lacerda, A. Pessoa et al., CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus, N. Engl. J. Med, vol.379, pp.220-232, 2011.

C. L. Walker, M. E. Little, J. A. Roby, B. Armistead, M. Gale et al., Zika virus and the non-microcephalic fetus: why we should still worry, Am. J. Obstet. Gynecol, vol.220, pp.45-56, 2018.

J. Wang, J. Liu, R. Zhou, X. Ding, Q. Zhang et al., Zika virus infected primary microglia impairs NPCs proliferation and differentiation, 2018.

, Biochem. Biophys. Res. Commun, vol.497, pp.619-625

Z. Wen, H. Song, M. , and G. L. , How does Zika virus cause microcephaly?, Genes Dev, vol.31, pp.849-861, 2017.

K. Y. Wu, G. L. Zuo, X. F. Li, Q. Ye, Y. Q. Deng et al., Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice, Cell Res, vol.26, pp.645-654, 2016.

C. Xu, B. Bailly-maitre, and J. C. Reed, Endoplasmic reticulum stress: cell life and death decisions, J. Clin. Invest, vol.115, pp.2656-2664, 2005.

L. Ye, Y. Huang, L. Zhao, Y. Li, L. Sun et al., IL-1beta and TNFalpha induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase, J. Neurochem, vol.125, pp.897-908, 2013.

F. Zhang, C. Hammack, S. C. Ogden, Y. Cheng, E. M. Lee et al., Molecular signatures associated with ZIKV exposure in human cortical neural progenitors, Nucleic Acids Res, vol.44, pp.8610-8620, 2016.

K. Zhang and R. J. Kaufman, From endoplasmic-reticulum stress to the inflammatory response, Nature, vol.24, pp.455-462, 2008.

K. Zukor, H. Wang, V. Siddharthan, J. G. Julander, and J. D. Morrey, Zika virus-induced acute myelitis and motor deficits in adult interferon alphabeta/gamma receptor knockout mice, J. Neurovirol, vol.24, pp.273-290, 2018.