Skip to Main content Skip to Navigation
Journal articles

The Unfolded Protein Response: A Key Player in Zika Virus-Associated Congenital Microcephaly

Abstract : Zika virus (ZIKV) is a mosquito-borne virus that belongs to the Flaviviridae family, together with dengue, yellow fever, and West Nile viruses. In the wake of its emergence in the French Polynesia and in the Americas, ZIKV has been shown to cause congenital microcephaly. It is the first arbovirus which has been proven to be teratogenic and sexually transmissible. Confronted with this major public health challenge, the scientific and medical communities teamed up to precisely characterize the clinical features of congenital ZIKV syndrome and its underlying pathophysiological mechanisms. This review focuses on the critical impact of the unfolded protein response (UPR) on ZIKV-associated congenital microcephaly. ZIKV infection of cortical neuron progenitors leads to high endoplasmic reticulum (ER) stress. This results in both the stalling of indirect neurogenesis, and UPR-dependent neuronal apoptotic death, and leads to cortical microcephaly. In line with these results, the administration of molecules inhibiting UPR prevents ZIKV-induced cortical microcephaly. The discovery of the link between ZIKV infection and UPR activation has a broader relevance, since this pathway plays a crucial role in many distinct cellular processes and its induction by ZIKV may account for several reported ZIKV-associated defects.
Complete list of metadatas

Cited literature [98 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02138159
Contributor : Andrée Diakite <>
Submitted on : Thursday, May 23, 2019 - 3:41:42 PM
Last modification on : Friday, October 23, 2020 - 4:43:47 PM

File

fncel-13-00094.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Christian Alfano, Ivan Gladwyn-Ng, Thérèse Couderc, Marc Lecuit, Laurent Nguyen. The Unfolded Protein Response: A Key Player in Zika Virus-Associated Congenital Microcephaly. Frontiers in Cellular Neuroscience, Frontiers, 2019, 13, ⟨10.3389/fncel.2019.00094⟩. ⟨pasteur-02138159⟩

Share

Metrics

Record views

360

Files downloads

854