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Journal articles
CD4 + T cell–mediated HLA class II cross-restriction in HIV controllers
Abstract : Rare individuals, termed HIV controllers, spontaneously control HIV infection by mounting efficient T cell responses against the virus. Protective CD4+ T cell responses from HIV controllers involve high-affinity public T cell receptors (TCRs) recognizing an immunodominant capsid epitope (Gag293) presented by a remarkably broad array of human leukocyte antigen (HLA) class II molecules. Here, we determine the structures of a prototypical public TCR bound to HLA-DR1, HLA-DR11, and HLA-DR15 molecules presenting the Gag293 epitope. TCR recognition was driven by contacts with the Gag293 epitope, a feature that underpinned the extensive HLA cross-restriction. These high-affinity TCRs promoted mature immunological synapse formation and cytotoxic capacity in both CD4+ and CD8+ T cells. The public TCRs suppressed HIV replication in multiple genetic backgrounds ex vivo, emphasizing the functional advantage conferred by broad HLA class II cross-restriction.
Cited literature [44 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02132543
Contributor : Florence Jeannot Connect in order to contact the contributor
Submitted on : Friday, May 17, 2019 - 11:34:43 AM
Last modification on : Wednesday, November 3, 2021 - 4:42:13 AM
Contributor : Florence Jeannot Connect in order to contact the contributor
Submitted on : Friday, May 17, 2019 - 11:34:43 AM
Last modification on : Wednesday, November 3, 2021 - 4:42:13 AM
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