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New Molecular Insights into Immune Cell Development

Abstract : During development innate lymphoid cells and specialized lymphocyte subsets colonize peripheral tissues, where they contribute to organogenesis and later constitute the first line of protection while maintaining tissue homeostasis. A few of these subsets are produced only during embryonic development and remain in the tissues throughout life. They are generated through a unique developmental program initiated in lympho-myeloid-primed progenitors, which lose myeloid and B cell potential. They either differentiate into innate lymphoid cells or migrate to the thymus to give rise to embryonic T cell receptor-invariant T cells. At later developmental stages, adaptive T lymphocytes are derived from lympho-myeloid progenitors that colonize the thymus, while lymphoid progenitors become specialized in the production of B cells. This sequence of events highlights the requirement for stratification in the establishment of immune functions that determine efficient seeding of peripheral tissues by a limited number of cells.
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Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Friday, May 3, 2019 - 3:02:20 PM
Last modification on : Thursday, April 7, 2022 - 10:10:36 AM



Ana Cumano, Claire Berthault, Cyrille Ramond, Maxime Petit, Rachel Golub, et al.. New Molecular Insights into Immune Cell Development. Annual Review of Immunology, 2019, 37 (1), pp.497-519. ⟨10.1146/annurev-immunol-042718-041319⟩. ⟨pasteur-02118987⟩



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