Viral Load Increases in SJL/J Mice Persistently Infected by Theiler's Virus after Inactivation of the 2m Gene

Stéphanie Aubagnac (1) , Michel Brahic (1) , Jean-François Bureau (1)

1 Virus Lents

We show that inactivating the beta(2)m gene increases the viral load of SJL/J mice persistently infected by Theiler's virus. Together with previous results, this shows that the characteristics of Tmevp1, a locus which controls the amount of viral RNA that persists in the central nervous system, are those of an H-2 class I gene.

Domains: Animal genetics; Virology

Stéphanie Aubagnac, Michel Brahic, Jean-François Bureau. Viral Load Increases in SJL/J Mice Persistently Infected by Theiler's Virus after Inactivation of the 2m Gene. Journal of Virology, 2001, 75 (16), pp.7723-7726. ⟨10.1128/JVI.75.16.7723-7726.2001⟩. ⟨pasteur-02097501⟩