Homology between a 173-kb Region from Mouse Chromosome 10, Telomeric to the Ifng Locus, and Human Chromosome 12q15

Soline Vigneau (1) , Florence Levillayer (1) , Hervé Crespeau (2) , Laurence Cattolico (2) , Bernard Caudron (3) , Franck Bihl (1) , Catherine Robert (2) , Michel Brahic (1) , Jean Weissenbach (2) , Jean-François Bureau (1)

1 Virus Lents
2 GENOSCOPE - Genoscope - Centre national de séquençage [Evry]
3 Centre d'Informatique pour la Biologie

We sequenced a 173-kb region of mouse chromosome 10, telomeric to the Ifng locus, and compared it with the human homologous sequence located on chromosome 12q15 using various sequence analysis programs. This region has a low density of genes: one gene was detected in the mouse and the human sequences and a second gene was detected only in the human sequence. The mouse gene and its human orthologue, which are expressed in the immune system at a low level, produce a noncoding mRNA. Nonexpressed sequences show a higher degree of conservation than exons in this genomic region. At least three of these conserved sequences are also conserved in a third mammalian species (sheep or cow).

Mots clés: comparative genome sequence analysis; mouse chromosome 10; interferon-ɣ; noncoding mRNA; conserved nonexpressed sequence

Domaines: Génétique animale

Soline Vigneau, Florence Levillayer, Hervé Crespeau, Laurence Cattolico, Bernard Caudron, et al.. Homology between a 173-kb Region from Mouse Chromosome 10, Telomeric to the Ifng Locus, and Human Chromosome 12q15. Genomics, 2001, 78 (3), pp.206-213. ⟨10.1006/geno.2001.6656⟩. ⟨pasteur-02097174⟩