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Homology between a 173-kb Region from Mouse Chromosome 10, Telomeric to the Ifng Locus, and Human Chromosome 12q15

Abstract : We sequenced a 173-kb region of mouse chromosome 10, telomeric to the Ifng locus, and compared it with the human homologous sequence located on chromosome 12q15 using various sequence analysis programs. This region has a low density of genes: one gene was detected in the mouse and the human sequences and a second gene was detected only in the human sequence. The mouse gene and its human orthologue, which are expressed in the immune system at a low level, produce a noncoding mRNA. Nonexpressed sequences show a higher degree of conservation than exons in this genomic region. At least three of these conserved sequences are also conserved in a third mammalian species (sheep or cow).
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Submitted on : Thursday, April 11, 2019 - 7:14:15 PM
Last modification on : Wednesday, June 17, 2020 - 3:42:03 PM

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Soline Vigneau, Florence Levillayer, Hervé Crespeau, Laurence Cattolico, Bernard Caudron, et al.. Homology between a 173-kb Region from Mouse Chromosome 10, Telomeric to the Ifng Locus, and Human Chromosome 12q15. Genomics, Elsevier, 2001, 78 (3), pp.206-213. ⟨10.1006/geno.2001.6656⟩. ⟨pasteur-02097174⟩

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