Bone Marrow Chimeras Reveal Non-H-2 Hematopoietic Control of Susceptibility to Theiler's Virus Persistent Infection - Archive ouverte HAL Access content directly
Journal Articles Journal of Virology Year : 2002

Bone Marrow Chimeras Reveal Non-H-2 Hematopoietic Control of Susceptibility to Theiler's Virus Persistent Infection

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Stéphanie Aubagnac
  • Function : Author
Michel Brahic
  • Function : Author
Jean-François Bureau
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Abstract

The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The respective roles of hematopoietic and nonhematopoietic cells in this difference have been evaluated with bone marrow chimeras. The results show that non-H-2 loci with a major effect on susceptibility are expressed in hematopoietic cells. However, the study of the SJL.B10-D10Mit180-D10Mit74 congenic line suggests that other loci expressed in nonhematopoietic cells also play a role.

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pasteur-02097169 , version 1 (11-04-2019)

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Stéphanie Aubagnac, Michel Brahic, Jean-François Bureau. Bone Marrow Chimeras Reveal Non-H-2 Hematopoietic Control of Susceptibility to Theiler's Virus Persistent Infection. Journal of Virology, 2002, 76 (11), pp.5807-5812. ⟨10.1128/JVI.76.11.5807-5812.2002⟩. ⟨pasteur-02097169⟩

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