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Journal articles
Bone Marrow Chimeras Reveal Non-H-2 Hematopoietic Control of Susceptibility to Theiler's Virus Persistent Infection
Abstract : The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The respective roles of hematopoietic and nonhematopoietic cells in this difference have been evaluated with bone marrow chimeras. The results show that non-H-2 loci with a major effect on susceptibility are expressed in hematopoietic cells. However, the study of the SJL.B10-D10Mit180-D10Mit74 congenic line suggests that other loci expressed in nonhematopoietic cells also play a role.
Cited literature [31 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02097169
Contributor : Jean-François Bureau Connect in order to contact the contributor
Submitted on : Thursday, April 11, 2019 - 7:05:37 PM
Last modification on : Tuesday, October 19, 2021 - 10:26:38 PM
Contributor : Jean-François Bureau Connect in order to contact the contributor
Submitted on : Thursday, April 11, 2019 - 7:05:37 PM
Last modification on : Tuesday, October 19, 2021 - 10:26:38 PM
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