Skip to Main content Skip to Navigation
Journal articles

Roles of the H-2D b and H-K b genes in resistance to persistent Theiler's murine encephalomyelitis virus infection of the central nervous system

Abstract : Theiler's murine encephalomyelitis virus, a member of the Picornaviridae family, persists in the spinal cord of susceptible strains of mice. Resistant strains of mice, such as the H-2 b strain, clear the virus infection after an acute encephalomyelitis. The H-2D locus, but not the H-2K locus, has a major effect on this resistance, although both loci code for MHC class I molecules with similar general properties. For the present work, we rendered susceptible H-2 q FVB/N mice transgenic for either the H-2D b gene, the H-2K b gene or a chimeric H-2D b /K b gene in which the exons encoding the peptide-binding groove of the H-2K b gene have been replaced by those of the H-2D b gene. Mice transgenic for either the H-2D b gene or the chimeric H-2D b /K b gene were significantly more resistant to persistent virus infection than mice transgenic for the H-2K b gene, suggesting that the difference in the effects of the H-2D b gene and the H-2K b gene are due to the nature of the peptides presented by these class I molecules.
Complete list of metadatas

Cited literature [19 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02097160
Contributor : Jean-François Bureau <>
Submitted on : Thursday, April 11, 2019 - 6:55:01 PM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM

Links full text

Identifiers

Collections

Citation

Arièle Azoulay-Cayla, Sylvie Syan, Michel Brahic, Jean-François Bureau. Roles of the H-2D b and H-K b genes in resistance to persistent Theiler's murine encephalomyelitis virus infection of the central nervous system. Journal of General Virology, Microbiology Society, 2001, 82, pp.1043 - 1047. ⟨10.1099/0022-1317-82-5-1043⟩. ⟨pasteur-02097160⟩

Share

Metrics

Record views

86