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Corticosteroid Therapy in Genotype ST-11 Meningococcal Infections.

Fouad Madhi 1, 2 Corinne Levy 2, 3, 4 Ala Eddine Deghmane 5 Stéphane Bechet 3, 4 Robert Cohen 1, 2, 3, 4 Muhamed-Kheir Taha 5, * 
* Corresponding author
1 Service de Pédiatrie [Créteil]
2 GPIP - Groupe de Pathologie Infectieuse Pédiatrique [Paris]
3 ACTIV - Association Clinique et Thérapeutique Infantile du Val de Marne
4 CRC - Centre de Recherche Clinique [Créteil]
5 CNR - Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae
Abstract : Corticosteroid treatment for meningococcal disease is debated. We report a high risk of death (odds ratio 4.68, 95% confidence interval: 1.91-11.46; P = 0.001) without corticosteroid treatment when meningococcal disease is provoked by isolates belonging to the hyperinvasive genotype ST-11. Genotypes of meningococcal isolates should be considered with corticosteroids therapy for meningococcal disease.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02092980
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Submitted on : Monday, April 8, 2019 - 3:36:43 PM
Last modification on : Thursday, April 7, 2022 - 10:10:25 AM

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Fouad Madhi, Corinne Levy, Ala Eddine Deghmane, Stéphane Bechet, Robert Cohen, et al.. Corticosteroid Therapy in Genotype ST-11 Meningococcal Infections.. Pediatric Infectious Disease Journal, Lippincott, Williams & Wilkins, 2013, 32 (3), pp.291-293. ⟨10.1097/INF.0b013e31827b12cb⟩. ⟨pasteur-02092980⟩

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