Corticosteroid Therapy in Genotype ST-11 Meningococcal Infections.

Fouad Madhi; Corinne Levy; Ala Eddine Deghmane; Stéphane Bechet; Robert Cohen; Muhamed-Kheir Taha

doi:10.1097/INF.0b013e31827b12cb

Journal articles

Corticosteroid Therapy in Genotype ST-11 Meningococcal Infections.

Fouad Madhi ^{1, 2} Corinne Levy ^{2, 3, 4} Ala Eddine Deghmane ⁵ Stéphane Bechet ^{3, 4} Robert Cohen ^{1, 2, 3, 4} Muhamed-Kheir Taha ^{5, *}

* Corresponding author

1 Service de Pédiatrie [Créteil]

2 GPIP - Groupe de Pathologie Infectieuse Pédiatrique [Paris]

3 ACTIV - Association Clinique et Thérapeutique Infantile du Val de Marne

4 CRC - Centre de Recherche Clinique [Créteil]

5 CNR - Centre National de Référence des Méningocoques-Infections Bactériennes Invasives

Abstract : Corticosteroid treatment for meningococcal disease is debated. We report a high risk of death (odds ratio 4.68, 95% confidence interval: 1.91-11.46; P = 0.001) without corticosteroid treatment when meningococcal disease is provoked by isolates belonging to the hyperinvasive genotype ST-11. Genotypes of meningococcal isolates should be considered with corticosteroids therapy for meningococcal disease.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Human health and pathology / Infectious diseases

Life Sciences [q-bio] / Human health and pathology / Pediatrics

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02092980
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Submitted on : Monday, April 8, 2019 - 3:36:43 PM
Last modification on : Monday, January 13, 2020 - 5:08:15 PM

Corticosteroid Therapy in Genotype ST-11 Meningococcal Infections.

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Corticosteroid Therapy in Genotype ST-11 Meningococcal Infections.

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