Corticosteroid Therapy in Genotype ST-11 Meningococcal Infections.

Fouad Madhi (1, 2) , Corinne Levy (2, 3, 4) , Ala Eddine Deghmane (5) , Stéphane Bechet (3, 4) , Robert Cohen (1, 2, 3, 4) , Muhamed-Kheir Taha (5)

1 Service de Pédiatrie [Créteil]
2 GPIP - Groupe de Pathologie Infectieuse Pédiatrique [Paris]
3 ACTIV - Association Clinique et Thérapeutique Infantile du Val de Marne
4 CRC - Centre de Recherche Clinique [Créteil]
5 CNR - Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae

Corticosteroid treatment for meningococcal disease is debated. We report a high risk of death (odds ratio 4.68, 95% confidence interval: 1.91-11.46; P = 0.001) without corticosteroid treatment when meningococcal disease is provoked by isolates belonging to the hyperinvasive genotype ST-11. Genotypes of meningococcal isolates should be considered with corticosteroids therapy for meningococcal disease.

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Human health and pathology; Pediatrics

Fouad Madhi, Corinne Levy, Ala Eddine Deghmane, Stéphane Bechet, Robert Cohen, et al.. Corticosteroid Therapy in Genotype ST-11 Meningococcal Infections.. Pediatric Infectious Disease Journal, 2013, 32 (3), pp.291-293. ⟨10.1097/INF.0b013e31827b12cb⟩. ⟨pasteur-02092980⟩