, The shiverer mutation affects the persistence of Theiler's tween a congenic line and the SJL/J strain showed that virus in the central nervous system, J. Virol, vol.71, pp.5025-5030

M. Brahic and J. F. Bureau, Genetics of susceptibility to Theiler's virus infection, BioEssays, vol.20, pp.627-633, 1998.

M. Brahic, W. G. Stroop, and J. R. Baringer, Theiler's virus of resistant alleles with mice with the (1,2), (2,1), and persists in glial cells during demyelinating disease, Cell, vol.26, p.123, 1981.

J. F. Bureau, X. Montagutelli, S. Lefebvre, J. L. Guénet, and M. , The interaction of two groups of murine genes loci. determines the persistence of Theiler's virus in the central nerInterestingly, this study showed that Ifng, a strong vous system, J. Virol, vol.66, pp.4698-4704, 1992.

J. F. Bureau, X. Montagutelli, F. Bihl, S. Lefebvre, and J. L. , Mapping loci influencing the persistence of Theiler's cluded from the regions containing Tmevp2 and Tmevp3. virus in the murine central nervous system, Nat. Genet, vol.5, pp.87-91, 1993.

P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform exon the expression pattern of the Ifng gene during the traction, This is consistent with recent data from our laboratory, vol.162, pp.156-159, 1987.

P. Monteyne, F. Bihl, and F. ,

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M. Levillayer and J. F. Brahic, Bureau, unpublished (CNS) disease in a murine model of multiple sclerosis. Immunol. results). Finally, it is interesting to note that our system Rev, vol.159, pp.177-193

L. Sevfiette, C. Aubert, U. Mü-ller, S. Huang, and M. Aguet, multigenic diseases, 1995.

, Theiler's virus infection of 129Sv mice that lack the interferon eral susceptibility loci are often located within genetic / or interferon receptors, J. Exp. Med, vol.181, pp.2069-2076

A. C. Kappel, R. W. Melvold, and B. S. Kim-;-podolin, on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis, J. Neuroimmunol, vol.29, pp.15-19, 1990.

E. S. Lander, P. Green, J. Abrahamson, A. Barlow, and M. J. , MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and of the persistent infection by Theiler's virus. Instead, natural populations, Genomics, vol.1, pp.174-181, 1987.

H. L. Lipton, J. Kratochvil, P. Sethi, and M. C. Canto, two susceptibility loci in the region. This study gives an Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection, Neurology, vol.34, pp.1117-1119, 1984.

H. L. Lipton, R. Melvold, S. D. Miller, and M. , Dal Canto, infections and illustrates the power of congenic mice 1995 Mutation of a major histocompatibility class I locus, Hto dissect such a control

, 2D, leads to an increased virus burden and disease susceptibility in Theiler's virus-induced demyelinating disease, J. Neurovirol. We thank S. Aubagnac and M. Tanguy for technical assistance, D, vol.1, pp.138-144

J. Gonzalez-dunia, X. Guénet, E. Montagutelli, P. Melanitou, E. Melanitou et al., Evidence for the presence of insulin-dependent diabetesassociated alleles on the distal part of mouse chromosome 6. This work was supported by the Institut Pasteur Fondation, the Genome Res, vol.8, pp.608-620, 1998.

C. Miller, S. , and S. Gerety, Immunologic aspects of Theiler's National de la Recherche Scientifique, the National Multiple Sclerosis murine encephalomyelitis virus (TMEV)-induced demyelinating Society, and the European Community Human Capital and Mobility disease, Association pour la Recherche sur la Sclérose en Plaques, the, vol.1, pp.263-272, 1990.

P. Program-;-monteyne, J. F. Bureau, and M. Brahic, The infection of arship from the Association pour la Recherche sur la Sclérose en mouse by Theiler's virus: from genetics to immunology, ImmuPlaques. nol. Rev, vol.159, pp.163-176, 1997.

P. Podolin, P. Denny, C. J. Lord, N. J. Hill, and J. A. Todd, Congenic mapping of the insulin-dependent diabetes (IDD) gene, IDD10, localizes two genes mediating the IDD10 effect and eliminates the candidate FCGR1, J. Immunol, vol.159, pp.1835-1843, 1997.

M. Rodriguez, C. S. David-;-h-2d-d-transgene-suppresses-azoulay, A. , M. Brahic, and J. F. Bureau, FVB mice transgenic Theiler's virus-induced demyelination in susceptible strains of for the H-2D b gene become resistant to persistent infection by mice, J. Neurovirol, vol.1, pp.111-117, 1994.

, Theiler's virus, J. Virol, vol.68, pp.4049-4052

F. Bihl, C. Pena-rossi, J. L. Guénet, M. Brahic, and J. F. Bureau,