FVB Mice Transgenic for the H-2Db Gene Become Resistant to Persistent Infection by Theiler's Virus - Archive ouverte HAL Access content directly
Journal Articles Journal of Virology Year : 1994

FVB Mice Transgenic for the H-2Db Gene Become Resistant to Persistent Infection by Theiler's Virus

(1) , (1) , (1)
1
Ariele Azoulay
  • Function : Author
Michel Brahic
  • Function : Correspondent author
  • PersonId : 1045476

Connectez-vous pour contacter l'auteur
Jean-François Bureau

Abstract

The DA strain of Theiler's virus causes a persistent infection of the white matter of the spinal cord with chronic inflammation and primary demyelination. Inbred strains of mice differ greatly in their susceptibility to this disease. It has been shown that both viral persistence and demyelination are controlled mainly by a gene located in the H-2D region. This raised the possibility that the H-2D gene itself controls viral persistence, which in turn determines demyelination. In the present work we introduced the H-2Db gene of resistant C57BL/6 mice into the genome of susceptible H-2q FVB mice and showed that the FVB mice become resistant to persistence of the infection and did not develop inflammatory lesions.

Dates and versions

pasteur-02090478 , version 1 (04-04-2019)

Identifiers

Cite

Ariele Azoulay, Michel Brahic, Jean-François Bureau. FVB Mice Transgenic for the H-2Db Gene Become Resistant to Persistent Infection by Theiler's Virus. Journal of Virology, 1994, 68 (6), pp.4049 - 4052. ⟨pasteur-02090478⟩

Collections

PASTEUR CNRS FRM
27 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More