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Laboratory evaluation of a rapid diagnostic test for Neisseria meningitidis serogroup A.

Aude Terrade 1 Jean-Marc Collard 2 Farida Nato 3 Muhamed-Kheir Taha 1, *
* Corresponding author
1 Centre National de Référence des Méningocoques-Centre Collaborateur de l'OMS pour les méningites bactériennes-Infections bactériennes invasives
2 CERMES - Centre de Recherche Médicale et Sanitaire (Niamey, Niger)
3 Production de Protéines Recombinantes et d'Anticorps (Plate-Forme)
Abstract : BACKGROUND: Epidemics of meningococcal meningitis occur periodically in the African 'meningitis belt' and are mainly, but not only, due to serogroup A. METHODS: We tested a dipstick as a rapid detection test (RDT) to detect serogroup A using 401 cerebrospinal fluid (CSF) samples. RESULTS: The detection limits were 10(5) CFU/ml with sensitivity and specificity for detecting serogroup A in CSF samples of 88% and 99%, respectively. CONCLUSIONS: The new RDT can be used in field surveillance of meningococcal meningitis to help characterize meningitis cases particularly after introduction of the conjugate vaccine against serogroup A.
Keywords : Diagnosis Meningitis Neisseria meningitidis Rapid test Serogroup A
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02088923
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Submitted on : Wednesday, April 3, 2019 - 12:09:45 PM
Last modification on : Monday, January 13, 2020 - 5:08:16 PM

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Aude Terrade, Jean-Marc Collard, Farida Nato, Muhamed-Kheir Taha. Laboratory evaluation of a rapid diagnostic test for Neisseria meningitidis serogroup A.. Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), 2013, 107 (7), pp.460-461. ⟨10.1093/trstmh/trt041⟩. ⟨pasteur-02088923⟩

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